Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2896326..2897035 Replicon chromosome
Accession NZ_CP041853
Organism Mycobacterium tuberculosis strain 1-0107P6C4

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ26
Locus tag FPJ55_RS13460 Protein ID WP_003413164.1
Coordinates 2896326..2896739 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P95006
Locus tag FPJ55_RS13465 Protein ID WP_003413167.1
Coordinates 2896778..2897035 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ55_RS13430 2891379..2892584 - 1206 WP_003413027.1 chorismate synthase -
FPJ55_RS13435 2892692..2893006 + 315 WP_009937839.1 hypothetical protein -
FPJ55_RS13440 2893302..2894513 + 1212 WP_003900845.1 alpha/beta hydrolase family protein -
FPJ55_RS13445 2894640..2895299 + 660 WP_003900846.1 LppA family lipoprotein -
FPJ55_RS13450 2895296..2895958 + 663 WP_023643170.1 hypothetical protein -
FPJ55_RS13455 2895955..2896233 + 279 WP_003901422.1 type II toxin-antitoxin system VapB family antitoxin -
FPJ55_RS13460 2896326..2896739 + 414 WP_003413164.1 PIN domain nuclease Toxin
FPJ55_RS13465 2896778..2897035 + 258 WP_003413167.1 ribbon-helix-helix domain-containing protein Antitoxin
FPJ55_RS13470 2897032..2897409 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
FPJ55_RS13475 2897425..2897799 - 375 WP_003413177.1 hypothetical protein -
FPJ55_RS13480 2897899..2898294 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 -
FPJ55_RS13485 2898291..2898536 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 -
FPJ55_RS13490 2898947..2899366 - 420 WP_003413190.1 A24 family peptidase -
FPJ55_RS13495 2899378..2900187 - 810 WP_003413193.1 shikimate dehydrogenase -
FPJ55_RS13500 2900184..2901437 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
FPJ55_RS13505 2901430..2901942 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15045.00 Da        Isoelectric Point: 5.4673

>T133221 WP_003413164.1 NZ_CP041853:2896326-2896739 [Mycobacterium tuberculosis]
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL

Download         Length: 414 bp

>T133221 NZ_CP041853:2896326-2896739 [Mycobacterium tuberculosis]
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9453.63 Da        Isoelectric Point: 10.6555

>AT133221 WP_003413167.1 NZ_CP041853:2896778-2897035 [Mycobacterium tuberculosis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Download         Length: 258 bp

>AT133221 NZ_CP041853:2896778-2897035 [Mycobacterium tuberculosis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ26

Antitoxin

Source ID Structure
AlphaFold DB A0A829C9W5

References