133168

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3100283..3100853 Replicon chromosome
Accession NZ_CP041852
Organism Mycobacterium tuberculosis strain 1-0110P6C4

Toxin (Protein)


Gene name mazF Uniprot ID P71650
Locus tag FPJ56_RS14600 Protein ID WP_003414166.1
Coordinates 3100283..3100639 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL61
Locus tag FPJ56_RS14605 Protein ID WP_003901465.1
Coordinates 3100623..3100853 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ56_RS14580 3095735..3097423 - 1689 WP_003414155.1 alpha/beta hydrolase family protein -
FPJ56_RS14585 3097427..3097753 - 327 WP_003414157.1 hypothetical protein -
FPJ56_RS14590 3097926..3098513 + 588 WP_003914429.1 DUF3558 family protein -
FPJ56_RS14595 3098532..3100181 + 1650 WP_003899485.1 CocE/NonD family hydrolase -
FPJ56_RS14600 3100283..3100639 - 357 WP_003414166.1 type II toxin-antitoxin system toxin endoribonuclease MazF9 Toxin
FPJ56_RS14605 3100623..3100853 - 231 WP_003901465.1 antitoxin MazE Antitoxin
FPJ56_RS14610 3100896..3101939 - 1044 WP_003414172.1 DUF2293 domain-containing protein -
FPJ56_RS14615 3102130..3102405 + 276 WP_003911993.1 DUF1778 domain-containing protein -
FPJ56_RS14620 3102581..3102835 - 255 WP_003917684.1 hypothetical protein -
FPJ56_RS14625 3102983..3103387 + 405 WP_003414181.1 hypothetical protein -
FPJ56_RS14630 3103384..3103575 + 192 WP_003414184.1 hypothetical protein -
FPJ56_RS14635 3103639..3104928 + 1290 Protein_2888 transposase family protein -
FPJ56_RS14640 3105162..3105419 + 258 WP_003899489.1 hypothetical protein -
FPJ56_RS14645 3105524..3105835 + 312 WP_003414190.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-29)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 12858.73 Da        Isoelectric Point: 9.1962

>T133168 WP_003414166.1 NZ_CP041852:c3100639-3100283 [Mycobacterium tuberculosis]
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS

Download         Length: 357 bp

>T133168 NZ_CP041852:c3100639-3100283 [Mycobacterium tuberculosis]
GTGATGCGCCGCGGTGAGATTTGGCAGGTCGATCTCGACCCCGCTCGAGGTAGCGAAGCGAACAACCAGCGCCCCGCCGT
CGTCGTCAGCAACGACCGGGCCAACGCGACCGCCACGCGTCTTGGGCGCGGCGTCATCACCGTCGTGCCGGTGACGAGCA
ACATCGCCAAGGTCTATCCGTTTCAGGTGTTGTTGTCGGCCACCACTACTGGTCTCCAGGTCGACTGCAAGGCGCAGGCC
GAGCAAATCAGATCGATTGCTACCGAGCGGTTGCTCCGGCCAATCGGCCGAGTTTCAGCCGCCGAACTTGCCCAGCTCGA
TGAGGCTTTGAAACTGCATCTCGACTTATGGTCGTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8231.01 Da        Isoelectric Point: 4.1809

>AT133168 WP_003901465.1 NZ_CP041852:c3100853-3100623 [Mycobacterium tuberculosis]
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR

Download         Length: 231 bp

>AT133168 NZ_CP041852:c3100853-3100623 [Mycobacterium tuberculosis]
GTGAAGTTGAGCGTGAGCCTGTCCGATGACGACGTCGCGATCCTGGACGCATATGTGAAACGAGCGGGATTACCATCCCG
CTCCGCCGGCCTGCAGCATGCGATCCGCGTGCTTCGCTACCCCACGCTCGAAGATGACTATGCCAACGCATGGCAAGAAT
GGTCGGCAGCCGGCGACACGGACGCGTGGGAGCAGACCGTCGGCGACGGAGTCGGTGATGCGCCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L2A
PDB 5HJZ
PDB 6KYT
PDB 6L29
PDB 7DU5
PDB 6KYS

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FBW3

References