133145

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1689656..1690272 Replicon chromosome
Accession NZ_CP041852
Organism Mycobacterium tuberculosis strain 1-0110P6C4

Toxin (Protein)


Gene name mazF Uniprot ID G0TJ74
Locus tag FPJ56_RS07855 Protein ID WP_003407593.1
Coordinates 1689955..1690272 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TJ73
Locus tag FPJ56_RS07850 Protein ID WP_003900349.1
Coordinates 1689656..1689958 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ56_RS07840 1685551..1687389 + 1839 WP_031676220.1 methylmalonyl-CoA mutase small subunit -
FPJ56_RS07845 1687390..1689642 + 2253 WP_003407587.1 methylmalonyl-CoA mutase -
FPJ56_RS07850 1689656..1689958 + 303 WP_003900349.1 type II toxin-antitoxin system antitoxin MazE4 Antitoxin
FPJ56_RS07855 1689955..1690272 + 318 WP_003407593.1 type II toxin-antitoxin system toxin endoribonuclease MazF4 Toxin
FPJ56_RS07860 1690269..1691273 + 1005 WP_003407596.1 methylmalonyl Co-A mutase-associated GTPase MeaB -
FPJ56_RS07865 1691326..1692615 + 1290 WP_003902090.1 serine hydrolase -
FPJ56_RS07870 1692688..1693461 - 774 WP_003912632.1 class I SAM-dependent methyltransferase -
FPJ56_RS07875 1693519..1693731 - 213 WP_003898900.1 dodecin family protein -
FPJ56_RS07880 1693741..1693965 - 225 WP_160522526.1 NUDIX domain-containing protein -
FPJ56_RS07885 1694235..1694483 + 249 Protein_1554 glycosyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-99)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11377.97 Da        Isoelectric Point: 7.9950

>T133145 WP_003407593.1 NZ_CP041852:1689955-1690272 [Mycobacterium tuberculosis]
VNAPLRGQVYRCDLGYGAKPWLIVSNNARNRHTADVVAVRLTTTRRTIPTWVAMGPSDPLTGYVNADNIETLGKDELGDY
LGEVTPATMNKINTALATALGLPWP

Download         Length: 318 bp

>T133145 NZ_CP041852:1689955-1690272 [Mycobacterium tuberculosis]
GTGAACGCGCCGTTGCGTGGTCAGGTCTATCGATGCGACCTCGGATACGGGGCCAAACCGTGGCTCATCGTCTCCAACAA
CGCCCGCAACCGTCACACCGCCGACGTGGTGGCTGTGCGCCTGACAACAACGCGGAGAACCATACCGACCTGGGTCGCCA
TGGGCCCCAGCGATCCATTGACCGGATACGTCAACGCGGACAACATCGAGACCCTCGGCAAAGACGAGCTCGGTGACTAC
CTCGGTGAGGTCACGCCGGCGACGATGAACAAAATCAACACGGCGCTCGCGACCGCGCTGGGGCTACCGTGGCCATGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11173.42 Da        Isoelectric Point: 9.5564

>AT133145 WP_003900349.1 NZ_CP041852:1689656-1689958 [Mycobacterium tuberculosis]
VPFLVALSGIISGVRDHSMTVRLDQQTRQRLQDIVKGGYRSANAAIVDAINKRWEALHDEQLDAAYAAAIHDNPAYPYES
EAERSAARARRNARQQRSAQ

Download         Length: 303 bp

>AT133145 NZ_CP041852:1689656-1689958 [Mycobacterium tuberculosis]
GTGCCGTTTCTGGTTGCATTATCCGGTATCATCTCGGGCGTGCGTGATCATTCGATGACCGTGCGGCTCGACCAGCAAAC
TCGCCAGCGCCTGCAAGACATTGTGAAAGGCGGATACCGGAGCGCTAATGCGGCGATCGTCGACGCCATCAACAAGCGCT
GGGAGGCGCTACACGATGAGCAACTCGACGCCGCCTACGCGGCCGCGATCCATGACAATCCGGCGTACCCGTACGAGTCT
GAGGCCGAACGGAGCGCCGCGCGGGCCCGGCGCAACGCCAGGCAGCAGCGCTCGGCACAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5XE3
PDB 5XE2

Antitoxin

Source ID Structure
AlphaFold DB G0TJ73

References