Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2929286..2930000 Replicon chromosome
Accession NZ_CP041851
Organism Mycobacterium tuberculosis strain 1-0112P6C4

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag FPJ57_RS13615 Protein ID WP_003413460.1
Coordinates 2929560..2930000 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag FPJ57_RS13610 Protein ID WP_003413456.1
Coordinates 2929286..2929573 (+) Length 96 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ57_RS13575 2924708..2924953 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
FPJ57_RS13580 2924950..2925354 + 405 WP_003413432.1 type II toxin-antitoxin system VapC family toxin -
FPJ57_RS13585 2925571..2926191 + 621 WP_003413441.1 DUF4178 domain-containing protein -
FPJ57_RS13590 2926202..2926696 + 495 WP_003413444.1 DUF2617 family protein -
FPJ57_RS13595 2926693..2927124 + 432 WP_003899390.1 DUF4247 domain-containing protein -
FPJ57_RS13600 2927149..2927607 + 459 WP_003413451.1 DUF350 domain-containing protein -
FPJ57_RS13605 2927604..2929175 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
FPJ57_RS13610 2929286..2929573 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
FPJ57_RS13615 2929560..2930000 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
FPJ57_RS13620 2930021..2930776 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
FPJ57_RS13625 2930909..2931505 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
FPJ57_RS13630 2931513..2932358 - 846 WP_003413466.1 acyl-CoA thioesterase II -
FPJ57_RS13635 2932387..2933286 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
FPJ57_RS13640 2933414..2934088 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-146)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T133106 WP_003413460.1 NZ_CP041851:2929560-2930000 [Mycobacterium tuberculosis]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T133106 NZ_CP041851:2929560-2930000 [Mycobacterium tuberculosis]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT133106 WP_003413456.1 NZ_CP041851:2929286-2929573 [Mycobacterium tuberculosis]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT133106 NZ_CP041851:2929286-2929573 [Mycobacterium tuberculosis]
ATGAAGACCACGCTCGACCTGCCTGATGAACTGATGCGCGCTATCAAGGTCCGCGCGGCGCAGCAGGGCCGCAAGATGAA
AGATGTCGTGACCGAACTGCTCAGATCCGGTCTGTCCCAGACGCACAGCGGGGCTCCAATCCCAACGCCGCGGCGCGTGC
AGCTTCCCCTGGTGCATTGCGGTGGCGCGGCTACCCGCGAACAAGAAATGACGCCGGAGCGTGTTGCCGCGGCCTTGCTC
GACCAGGAGGCCCAGTGGTGGTCCGGACACGACGATGCTGCTCTGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G0TQK0


Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References