Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3176141..3176828 Replicon chromosome
Accession NZ_CP041849
Organism Mycobacterium tuberculosis strain 1-0123P6C4

Toxin (Protein)


Gene name vapC Uniprot ID P65044
Locus tag FPJ59_RS15005 Protein ID WP_003414624.1
Coordinates 3176385..3176828 (+) Length 148 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TFH0
Locus tag FPJ59_RS15000 Protein ID WP_003414620.1
Coordinates 3176141..3176398 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ59_RS14980 3171461..3172315 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
FPJ59_RS14985 3172371..3173534 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
FPJ59_RS14990 3173551..3174765 - 1215 WP_003414610.1 zinc metalloprotease Rip -
FPJ59_RS14995 3174773..3176014 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -
FPJ59_RS15000 3176141..3176398 + 258 WP_003414620.1 ribbon-helix-helix domain-containing protein Antitoxin
FPJ59_RS15005 3176385..3176828 + 444 WP_003414624.1 type II toxin-antitoxin system VapC family toxin Toxin
FPJ59_RS15010 3176908..3177570 + 663 WP_003414630.1 cell surface glycolipoprotein Mpt83 -
FPJ59_RS15015 3177666..3177857 + 192 WP_003414632.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FPJ59_RS15020 3178189..3179937 + 1749 WP_003912869.1 cytochrome c biogenesis protein DipZ -
FPJ59_RS15025 3180033..3180614 + 582 WP_003414644.1 fasciclin domain-containing protein -
FPJ59_RS15030 3180714..3180980 + 267 WP_015456449.1 DUF2631 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 148 a.a.        Molecular weight: 16595.72 Da        Isoelectric Point: 6.4890

>T132994 WP_003414624.1 NZ_CP041849:3176385-3176828 [Mycobacterium tuberculosis]
MLCVDVNVLVYAHRADLREHADYRGLLERLANDDEPLGLPDSVLAGFIRVVTNRRVFTEPTSPQDAWQAVDALLAAPAAM
RLRPGERHWMAFRQLASDVDANGNDIADAHLAAYALENNATWLSADRGFARFRRLRWRHPLDGQTHL

Download         Length: 444 bp

>T132994 NZ_CP041849:3176385-3176828 [Mycobacterium tuberculosis]
ATGCTGTGCGTTGATGTCAACGTGCTCGTTTACGCGCATCGGGCAGACCTACGGGAGCACGCGGACTATCGGGGTTTGCT
TGAGCGGCTGGCCAACGATGACGAGCCGCTGGGTCTACCAGATAGCGTGCTCGCCGGCTTCATCCGGGTGGTTACCAACC
GCCGCGTCTTCACCGAGCCGACGAGCCCACAGGACGCATGGCAGGCAGTCGACGCCCTACTCGCGGCACCCGCAGCCATG
CGACTTCGGCCTGGCGAGCGCCACTGGATGGCCTTTCGGCAGTTAGCGTCCGATGTTGATGCGAACGGCAACGACATTGC
GGACGCGCACCTGGCCGCCTACGCGCTAGAGAACAACGCAACCTGGTTGAGCGCCGACCGCGGCTTTGCCCGTTTCCGTC
GACTGCGCTGGCGTCATCCGTTGGACGGTCAGACCCATCTATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9013.22 Da        Isoelectric Point: 10.8344

>AT132994 WP_003414620.1 NZ_CP041849:3176141-3176398 [Mycobacterium tuberculosis]
VRTTIRIDDELYREVKAKAARSGRTVAAVLEDAVRRGLNPPKPQAAGRYRVQPSGKGGLRPGVDLSSNAALAEAMNDGVS
VDAVR

Download         Length: 258 bp

>AT132994 NZ_CP041849:3176141-3176398 [Mycobacterium tuberculosis]
GTGCGCACGACGATCCGTATCGATGACGAGCTGTACCGCGAGGTGAAAGCAAAGGCCGCTCGTTCCGGGCGTACCGTGGC
CGCGGTTCTTGAAGATGCGGTGCGGCGTGGTCTCAACCCGCCTAAGCCGCAGGCCGCCGGCCGTTATCGAGTCCAGCCGT
CGGGTAAGGGCGGCCTGCGGCCCGGTGTCGATCTATCGTCCAACGCCGCACTTGCCGAAGCGATGAACGACGGCGTGTCG
GTCGATGCTGTGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VWO

Antitoxin

Source ID Structure
PDB 7VWO
AlphaFold DB G0TFH0

References