Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2804270..2804922 Replicon chromosome
Accession NZ_CP041848
Organism Mycobacterium tuberculosis strain 1-0137P6C4

Toxin (Protein)


Gene name vapC Uniprot ID A0A5R1ZCY8
Locus tag FPJ60_RS13040 Protein ID WP_003905869.1
Coordinates 2804497..2804922 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ24
Locus tag FPJ60_RS13035 Protein ID WP_003412749.1
Coordinates 2804270..2804491 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ60_RS13020 2802510..2802716 - 207 WP_003899347.1 hypothetical protein -
FPJ60_RS13025 2802852..2803475 + 624 WP_003900858.1 TIGR00725 family protein -
FPJ60_RS13030 2803465..2804217 + 753 WP_003901416.1 hypothetical protein -
FPJ60_RS13035 2804270..2804491 + 222 WP_003412749.1 antitoxin Antitoxin
FPJ60_RS13040 2804497..2804922 + 426 WP_003905869.1 type II toxin-antitoxin system VapC family toxin Toxin
FPJ60_RS13045 2804945..2806126 - 1182 WP_003905870.1 2-oxo acid dehydrogenase subunit E2 -
FPJ60_RS13050 2806123..2807169 - 1047 WP_003412757.1 3-methyl-2-oxobutanoate dehydrogenase subunit beta -
FPJ60_RS13055 2807180..2808283 - 1104 WP_003412761.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
FPJ60_RS13060 2808542..2809363 - 822 WP_003412766.1 citrate (pro-3S)-lyase subunit beta -
FPJ60_RS13065 2809360..2809917 - 558 WP_003412768.1 MaoC family dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15364.84 Da        Isoelectric Point: 9.2386

>T132921 WP_003905869.1 NZ_CP041848:2804497-2804922 [Mycobacterium tuberculosis]
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRASTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL

Download         Length: 426 bp

>T132921 NZ_CP041848:2804497-2804922 [Mycobacterium tuberculosis]
GTGGCGCTGCTCGACGTCAACGCATTGGTCGCGCTGGCGTGGGACTCACACATCCACCACGCCCGGATCCGCGAGTGGTT
TACCGCCAACGCCACGCTCGGCTGGGCGACTTGCCCGCTCACCGAAGCCGGCTTCGTGCGGGCGTCGACGAACCCAAAAG
TACTTCCCAGCGCGATCGGGATCGCAGACGCTCGACGGGTCCTCGTGGCACTACGCGCCGTGGGAGGCCACCGCTTCCTG
GCTGACGACGTATCGCTCGTCGATGACGATGTTCCGTTGATCGTCGGTTATCGCCAGGTGACCGACGCCCATCTGCTGAC
ACTCGCCCGCCGGCGCGGCGTCCGCCTGGTCACCTTCGACGCCGGTGTCTTCACCCTCGCCCAACAACGCCCCAAGACGC
CAGTGGAGCTGCTGACCATCCTCTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7864.93 Da        Isoelectric Point: 4.5258

>AT132921 WP_003412749.1 NZ_CP041848:2804270-2804491 [Mycobacterium tuberculosis]
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDED

Download         Length: 222 bp

>AT132921 NZ_CP041848:2804270-2804491 [Mycobacterium tuberculosis]
GTGCGAACGACACTTGACCTTGACGACGATGTGATCGCCGCGGCACGTGAACTTGCCTCCAGCCAGCGCCGCTCGCTCGG
CTCGGTGATTTCCGAACTCGCACGCCGTGGTCTCATGCCCGGACGCGTCGAGGCTGACGACGGGCTGCCGGTGATCCGCG
TTCCAGCCGGGACCCCGCCGATCACACCGGAGATGGTCCGTCGCGCGCTCGATGAGGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5R1ZCY8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW03

References