Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2402408..2402937 Replicon chromosome
Accession NZ_CP041848
Organism Mycobacterium tuberculosis strain 1-0137P6C4

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag FPJ60_RS11160 Protein ID WP_003411124.1
Coordinates 2402408..2402725 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag FPJ60_RS11165 Protein ID WP_003411127.1
Coordinates 2402722..2402937 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ60_RS11130 2397429..2398505 + 1077 WP_003411110.1 hypothetical protein -
FPJ60_RS11135 2398502..2398783 + 282 WP_003411112.1 hypothetical protein -
FPJ60_RS11140 2398819..2399892 + 1074 WP_003901338.1 quinone-dependent dihydroorotate dehydrogenase -
FPJ60_RS11145 2399897..2400427 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
FPJ60_RS11150 2400475..2401821 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
FPJ60_RS11160 2402408..2402725 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FPJ60_RS11165 2402722..2402937 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
FPJ60_RS11170 2403192..2404250 + 1059 WP_003411129.1 hypothetical protein -
FPJ60_RS11175 2404380..2404736 - 357 WP_003411130.1 hypothetical protein -
FPJ60_RS11180 2404831..2405613 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
FPJ60_RS11185 2405881..2406171 - 291 WP_003900476.1 YggT family protein -
FPJ60_RS11190 2406333..2406989 - 657 WP_003411133.1 cell division protein SepF -
FPJ60_RS11195 2407051..2407830 - 780 WP_015575160.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T132920 WP_003411124.1 NZ_CP041848:c2402725-2402408 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T132920 NZ_CP041848:c2402725-2402408 [Mycobacterium tuberculosis]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT132920 WP_003411127.1 NZ_CP041848:c2402937-2402722 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT132920 NZ_CP041848:c2402937-2402722 [Mycobacterium tuberculosis]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References