Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2219138..2219826 Replicon chromosome
Accession NZ_CP041848
Organism Mycobacterium tuberculosis strain 1-0137P6C4

Toxin (Protein)


Gene name vapC Uniprot ID P0A653
Locus tag FPJ60_RS10300 Protein ID WP_003409958.1
Coordinates 2219138..2219557 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag FPJ60_RS10305 Protein ID WP_003409968.1
Coordinates 2219566..2219826 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ60_RS10280 2214634..2215482 + 849 WP_003901306.1 class I SAM-dependent methyltransferase -
FPJ60_RS10285 2215445..2216889 - 1445 Protein_2032 APC family permease -
FPJ60_RS10290 2217068..2217754 - 687 WP_003409954.1 immunoprotective protein Mpt64 -
FPJ60_RS10295 2217945..2218913 - 969 WP_003899116.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
FPJ60_RS10300 2219138..2219557 - 420 WP_003409958.1 type II toxin-antitoxin system VapC family toxin Toxin
FPJ60_RS10305 2219566..2219826 - 261 WP_003409968.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
FPJ60_RS10310 2219969..2221645 + 1677 WP_003899118.1 PecA family PE domain-processing aspartic protease -
FPJ60_RS10315 2221633..2222286 - 654 WP_003409976.1 cutinase Cfp21 -
FPJ60_RS10320 2222401..2222631 + 231 WP_003409980.1 DUF167 domain-containing protein -
FPJ60_RS10325 2222716..2223627 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
FPJ60_RS10330 2223736..2224335 + 600 WP_003910883.1 L-lysine exporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14724.89 Da        Isoelectric Point: 7.9535

>T132913 WP_003409958.1 NZ_CP041848:c2219557-2219138 [Mycobacterium tuberculosis]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Download         Length: 420 bp

>T132913 NZ_CP041848:c2219557-2219138 [Mycobacterium tuberculosis]
ATGATCGTGGACACAAGCGCCGTGGTGGCCCTGGTTCAAGGCGAGCGGCCGCACGCCACCCTGGTCGCGGCCGCCCTGGC
CGGCGCCCATAGCCCCGTCATGTCTGCACCCACCGTCGCCGAATGCCTGATTGTCTTGACCGCCCGTCACGGCCCCGTTG
CGCGCACGATCTTCGAACGACTTCGCAGCGAAATCGGCTTGAGCGTGTCATCTTTCACCGCCGAGCATGCCGCTGCCACG
CAACGAGCCTTTCTGCGATACGGCAAGGGGCGCCACCGCGCGGCTCTCAACTTCGGAGACTGTATGACGTACGCGACCGC
CCAGCTGGGCCACCAACCACTGCTGGCCGTCGGCAACGACTTCCCGCAAACCGACCTTGAGTTCCGCGGCGTCGTCGGCT
ACTGGCCAGGCGTCGCGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT132913 WP_003409968.1 NZ_CP041848:c2219826-2219566 [Mycobacterium tuberculosis]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp

>AT132913 NZ_CP041848:c2219826-2219566 [Mycobacterium tuberculosis]
GTGGCGCTGAATATCAAAGACCCTGAGGTAGACCGACTAGCCGCCGAACTCGCTGACCGGCTGCACACCAGCAAGACTGC
CGCCATCCGGCATGCCCTGTCTGCCCAGCTGGCGTTTTTGGAGTCGCGCGCCGGCGACCGTGAGGCACAACTTCTCGACA
TCTTGCGTACCGAAATCTGGCCCCTGCTTGCCGACCGCTCCCCCATCACCAAGCTCGAGCGCGAACAAATCCTCGGCTAC
GACCCCGCAACCGGAGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C4H9

Antitoxin

Source ID Structure
AlphaFold DB A0A829C483

References