Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2192914..2193458 Replicon chromosome
Accession NZ_CP041848
Organism Mycobacterium tuberculosis strain 1-0137P6C4

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag FPJ60_RS10145 Protein ID WP_003409896.1
Coordinates 2192914..2193210 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag FPJ60_RS10150 Protein ID WP_003409899.1
Coordinates 2193207..2193458 (-) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ60_RS10090 2187947..2188297 - 351 WP_003409871.1 hypothetical protein -
FPJ60_RS10095 2188308..2189210 - 903 WP_003899097.1 hypothetical protein -
FPJ60_RS10100 2189231..2189422 - 192 WP_003409876.1 hypothetical protein -
FPJ60_RS10105 2189423..2189719 - 297 WP_003409877.1 hypothetical protein -
FPJ60_RS10110 2189959..2190174 + 216 WP_003409878.1 antitoxin -
FPJ60_RS10115 2190171..2190482 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
FPJ60_RS10120 2190456..2190977 - 522 WP_003904745.1 hypothetical protein -
FPJ60_RS10125 2190952..2191329 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB -
FPJ60_RS10130 2191371..2191820 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA -
FPJ60_RS10135 2191817..2192362 + 546 WP_003409891.1 SecB-like chaperone -
FPJ60_RS10140 2192251..2192865 - 615 WP_003901296.1 hypothetical protein -
FPJ60_RS10145 2192914..2193210 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FPJ60_RS10150 2193207..2193458 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
FPJ60_RS10155 2193445..2193939 + 495 WP_003899099.1 hypothetical protein -
FPJ60_RS10160 2194099..2194506 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
FPJ60_RS10165 2194510..2194782 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FPJ60_RS10170 2194815..2196035 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
FPJ60_RS10175 2196934..2197731 + 798 WP_003899101.1 ABC transporter permease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-93)

Antitoxin

(2-80)


Sequences


Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T132912 WP_003409896.1 NZ_CP041848:c2193210-2192914 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T132912 NZ_CP041848:c2193210-2192914 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT132912 WP_003409899.1 NZ_CP041848:c2193458-2193207 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT132912 NZ_CP041848:c2193458-2193207 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G0TLU9


Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BUZ2

References