Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2183877..2184580 Replicon chromosome
Accession NZ_CP041848
Organism Mycobacterium tuberculosis strain 1-0137P6C4

Toxin (Protein)


Gene name mazF Uniprot ID G0TLK7
Locus tag FPJ60_RS10055 Protein ID WP_003409778.1
Coordinates 2183877..2184206 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TLK8
Locus tag FPJ60_RS10060 Protein ID WP_003409780.1
Coordinates 2184203..2184580 (-) Length 126 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ60_RS10035 2180260..2181330 + 1071 WP_003902252.1 epoxide hydrolase EphB -
FPJ60_RS10040 2181327..2181842 + 516 WP_015575134.1 flavin reductase family protein -
FPJ60_RS10045 2181839..2182900 + 1062 WP_003899092.1 3,4-dihydroxy-2-butanone-4-phosphate synthase -
FPJ60_RS10050 2182897..2183667 + 771 WP_003409775.1 SDR family oxidoreductase -
FPJ60_RS10055 2183877..2184206 - 330 WP_003409778.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
FPJ60_RS10060 2184203..2184580 - 378 WP_003409780.1 type II toxin-antitoxin system antitoxin MazE5 Antitoxin
FPJ60_RS10065 2184577..2185167 - 591 WP_003409784.1 SEC-C domain-containing protein -
FPJ60_RS10070 2185222..2186586 + 1365 WP_003903691.1 HNH endonuclease -
FPJ60_RS10075 2186741..2187193 - 453 WP_003899095.1 lipoprotein -
FPJ60_RS10080 2187257..2187658 + 402 WP_003409869.1 hypothetical protein -
FPJ60_RS10085 2187651..2187833 - 183 WP_003409870.1 hypothetical protein -
FPJ60_RS10090 2187947..2188297 - 351 WP_003409871.1 hypothetical protein -
FPJ60_RS10095 2188308..2189210 - 903 WP_003899097.1 hypothetical protein -
FPJ60_RS10100 2189231..2189422 - 192 WP_003409876.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(7-103)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 110 a.a.        Molecular weight: 11787.82 Da        Isoelectric Point: 8.5361

>T132910 WP_003409778.1 NZ_CP041848:c2184206-2183877 [Mycobacterium tuberculosis]
VTALPARGEVWWCEMAEIGRRPVVVLSRDAAIPRLRRALVAPCTTTIRGLASEVVLEPGSDPIPRRSAVNLDSVESVSVA
VLVNRLGRLADIRMRAICTALEVAVDCSR

Download         Length: 330 bp

>T132910 NZ_CP041848:c2184206-2183877 [Mycobacterium tuberculosis]
GTGACCGCACTTCCGGCGCGCGGAGAGGTGTGGTGGTGTGAGATGGCTGAGATCGGTCGGCGACCAGTCGTCGTGCTGTC
GCGCGATGCCGCGATCCCTCGGCTGCGACGCGCACTTGTCGCGCCCTGCACCACGACCATCCGAGGGCTAGCCAGTGAGG
TTGTTCTTGAACCCGGTTCCGACCCGATCCCGCGCCGTTCCGCGGTGAATTTGGACTCAGTCGAAAGTGTCTCGGTCGCG
GTATTGGTGAATCGGCTTGGCCGCCTCGCCGACATCCGGATGCGCGCCATCTGCACGGCCCTCGAGGTCGCCGTCGATTG
CTCTCGATGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13560.07 Da        Isoelectric Point: 5.1519

>AT132910 WP_003409780.1 NZ_CP041848:c2184580-2184203 [Mycobacterium tuberculosis]
VKTARLQVTLRCAVDLINSSSDQCFARIEHVASDQADPRPGVWHSSGMNRIRLSTTVDAALLTSARDMRAGITDAALIDE
ALAALLARHRSAEVDASYAAYDKHPVDEPDEWGDLASWRRAAGDS

Download         Length: 378 bp

>AT132910 NZ_CP041848:c2184580-2184203 [Mycobacterium tuberculosis]
GTGAAGACGGCCCGGTTGCAGGTGACGTTGCGCTGCGCGGTAGACCTCATCAATTCGTCCAGCGACCAATGTTTCGCCCG
TATCGAGCACGTTGCGTCCGATCAGGCGGATCCACGCCCCGGAGTGTGGCATAGTAGTGGCATGAATCGCATACGGCTGA
GCACTACTGTCGACGCCGCACTCTTGACAAGTGCGCGCGACATGCGGGCAGGAATCACTGACGCAGCCCTCATCGATGAG
GCCCTTGCGGCATTACTGGCTCGTCATCGATCGGCCGAGGTGGATGCCAGCTATGCGGCCTACGACAAGCACCCGGTCGA
TGAGCCCGACGAGTGGGGCGATCTAGCGTCGTGGCGGCGGGCGGCTGGAGACTCGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G0TLK7


Antitoxin

Source ID Structure
AlphaFold DB G0TLK8

References