Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/AbrB(antitoxin)
Location 695452..696098 Replicon chromosome
Accession NZ_CP041848
Organism Mycobacterium tuberculosis strain 1-0137P6C4

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ88
Locus tag FPJ60_RS03115 Protein ID WP_003403137.1
Coordinates 695452..695865 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ89
Locus tag FPJ60_RS03120 Protein ID WP_003403139.1
Coordinates 695862..696098 (-) Length 79 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ60_RS03095 691535..693085 + 1551 WP_003905349.1 MCE family protein -
FPJ60_RS03100 693137..693529 - 393 WP_003403122.1 type II toxin-antitoxin system toxin ribonuclease C4 -
FPJ60_RS03105 693526..693783 - 258 WP_003403125.1 type II toxin-antitoxin system antitoxin VapB4 -
FPJ60_RS03110 693966..695201 - 1236 WP_003403128.1 ATP-binding protein -
FPJ60_RS03115 695452..695865 - 414 WP_003403137.1 type II toxin-antitoxin system VapC family toxin Toxin
FPJ60_RS03120 695862..696098 - 237 WP_003403139.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
FPJ60_RS03125 696202..696708 - 507 WP_003900973.1 two component system sensor kinase HK1 -
FPJ60_RS03130 696822..697352 - 531 WP_003917320.1 two component system sensor kinase HK2 -
FPJ60_RS03135 697336..698097 - 762 WP_003403148.1 two-component system response regulator TcrA -
FPJ60_RS03140 698154..698465 + 312 WP_003403164.1 hypothetical protein -
FPJ60_RS03145 698537..699487 + 951 WP_003900184.1 DUF1259 domain-containing protein -
FPJ60_RS03150 699728..700312 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
FPJ60_RS03155 700314..701024 + 711 Protein_625 transposase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(7-126)

Antitoxin

(3-43)


Sequences


Toxin        


Download         Length: 138 a.a.        Molecular weight: 14786.14 Da        Isoelectric Point: 8.1405

>T132888 WP_003403137.1 NZ_CP041848:c695865-695452 [Mycobacterium tuberculosis]
VKPPLAVDTSVAIPLLVRTHTAHAAVVAWWAHREAALCGHALAETYSVLTRLPRDLRLAPMDAARLLTERFAAPLLLSSR
TTEHLPRVLAQFEITGGAVYDALVALAAAEHRAELATRDARAKDTYEKIGVHVVVAA

Download         Length: 414 bp

>T132888 NZ_CP041848:c695865-695452 [Mycobacterium tuberculosis]
GTGAAACCGCCGCTGGCAGTGGACACCAGCGTCGCGATTCCGTTGCTGGTACGGACCCATACCGCGCATGCGGCGGTTGT
CGCCTGGTGGGCACATCGGGAGGCCGCGCTGTGCGGGCACGCCCTGGCCGAAACCTACTCCGTGCTGACCCGCCTGCCGC
GTGACCTACGACTGGCACCGATGGACGCCGCGCGGCTTCTTACCGAACGCTTTGCGGCACCGCTGTTGTTGAGTTCCCGC
ACCACTGAACATCTCCCACGCGTGCTGGCCCAATTCGAGATCACTGGTGGCGCGGTCTATGACGCTCTCGTGGCCCTTGC
CGCCGCCGAGCACCGGGCTGAACTCGCCACACGCGATGCTCGAGCCAAGGACACTTACGAAAAGATCGGCGTCCACGTCG
TTGTCGCCGCGTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8212.41 Da        Isoelectric Point: 5.0351

>AT132888 WP_003403139.1 NZ_CP041848:c696098-695862 [Mycobacterium tuberculosis]
MKAVVDAAGRIVVPKPLREALGLQPGSTVEISRYGAGLHLIPTGRTARLEEENGVLVATGETTIDDEVVFGLIDSGRK

Download         Length: 237 bp

>AT132888 NZ_CP041848:c696098-695862 [Mycobacterium tuberculosis]
ATGAAGGCTGTTGTGGATGCGGCTGGCCGCATCGTCGTACCCAAACCGCTGCGCGAAGCCTTGGGGCTGCAACCGGGGTC
CACCGTGGAAATATCCCGCTATGGCGCTGGTCTCCACCTGATTCCCACCGGACGAACAGCGCGTCTCGAAGAGGAGAATG
GCGTACTGGTGGCCACCGGTGAGACCACGATCGACGATGAGGTCGTGTTCGGCCTTATCGATAGCGGCCGGAAGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G0TQ88


Antitoxin

Source ID Structure
AlphaFold DB G0TQ89

References