Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2865836..2866545 Replicon chromosome
Accession NZ_CP041847
Organism Mycobacterium tuberculosis strain 1-0149P6C4

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ26
Locus tag FPJ61_RS13325 Protein ID WP_003413164.1
Coordinates 2865836..2866249 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P95006
Locus tag FPJ61_RS13330 Protein ID WP_003413167.1
Coordinates 2866288..2866545 (+) Length 86 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ61_RS13295 2860891..2862096 - 1206 WP_003413027.1 chorismate synthase -
FPJ61_RS13300 2862204..2862518 + 315 WP_009937839.1 hypothetical protein -
FPJ61_RS13305 2862814..2864025 + 1212 WP_003900845.1 alpha/beta hydrolase family protein -
FPJ61_RS13310 2864152..2864811 + 660 WP_003902296.1 hypothetical protein -
FPJ61_RS13315 2864808..2865469 + 662 Protein_2628 hypothetical protein -
FPJ61_RS13320 2865466..2865743 + 278 Protein_2629 type II toxin-antitoxin system VapB family antitoxin -
FPJ61_RS13325 2865836..2866249 + 414 WP_003413164.1 PIN domain nuclease Toxin
FPJ61_RS13330 2866288..2866545 + 258 WP_003413167.1 ribbon-helix-helix domain-containing protein Antitoxin
FPJ61_RS13335 2866542..2866919 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
FPJ61_RS13340 2866935..2867309 - 375 WP_003413177.1 hypothetical protein -
FPJ61_RS13345 2867409..2867804 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 -
FPJ61_RS13350 2867801..2868046 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 -
FPJ61_RS13355 2868457..2868876 - 420 WP_003413190.1 A24 family peptidase -
FPJ61_RS13360 2868888..2869697 - 810 WP_003413193.1 shikimate dehydrogenase -
FPJ61_RS13365 2869694..2870947 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
FPJ61_RS13370 2870940..2871452 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-122)

Antitoxin

(2-38)


Sequences


Toxin        


Download         Length: 138 a.a.        Molecular weight: 15045.00 Da        Isoelectric Point: 5.4673

>T132863 WP_003413164.1 NZ_CP041847:2865836-2866249 [Mycobacterium tuberculosis]
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL

Download         Length: 414 bp

>T132863 NZ_CP041847:2865836-2866249 [Mycobacterium tuberculosis]
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9453.63 Da        Isoelectric Point: 10.6555

>AT132863 WP_003413167.1 NZ_CP041847:2866288-2866545 [Mycobacterium tuberculosis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Download         Length: 258 bp

>AT132863 NZ_CP041847:2866288-2866545 [Mycobacterium tuberculosis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G0TQ26


Antitoxin

Source ID Structure
AlphaFold DB A0A829C9W5

References