Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2864100..2864809 Replicon chromosome
Accession NZ_CP041846
Organism Mycobacterium tuberculosis strain 1-0153P6C4

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ26
Locus tag FPJ62_RS13285 Protein ID WP_003413164.1
Coordinates 2864100..2864513 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P95006
Locus tag FPJ62_RS13290 Protein ID WP_003413167.1
Coordinates 2864552..2864809 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ62_RS13255 2859154..2860359 - 1206 WP_003413027.1 chorismate synthase -
FPJ62_RS13260 2860467..2860781 + 315 WP_009937839.1 hypothetical protein -
FPJ62_RS13265 2861077..2862288 + 1212 WP_003900845.1 alpha/beta hydrolase family protein -
FPJ62_RS13270 2862415..2863074 + 660 WP_003902296.1 hypothetical protein -
FPJ62_RS13275 2863071..2863733 + 663 WP_003905878.1 hypothetical protein -
FPJ62_RS13280 2863730..2864007 + 278 Protein_2621 type II toxin-antitoxin system VapB family antitoxin -
FPJ62_RS13285 2864100..2864513 + 414 WP_003413164.1 PIN domain nuclease Toxin
FPJ62_RS13290 2864552..2864809 + 258 WP_003413167.1 ribbon-helix-helix domain-containing protein Antitoxin
FPJ62_RS13295 2864806..2865183 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
FPJ62_RS13300 2865199..2865573 - 375 WP_003413177.1 hypothetical protein -
FPJ62_RS13305 2865673..2866068 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 -
FPJ62_RS13310 2866065..2866310 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 -
FPJ62_RS13315 2866721..2867140 - 420 WP_003413190.1 A24 family peptidase -
FPJ62_RS13320 2867152..2867961 - 810 WP_003413193.1 shikimate dehydrogenase -
FPJ62_RS13325 2867958..2869211 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
FPJ62_RS13330 2869204..2869716 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15045.00 Da        Isoelectric Point: 5.4673

>T132803 WP_003413164.1 NZ_CP041846:2864100-2864513 [Mycobacterium tuberculosis]
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL

Download         Length: 414 bp

>T132803 NZ_CP041846:2864100-2864513 [Mycobacterium tuberculosis]
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9453.63 Da        Isoelectric Point: 10.6555

>AT132803 WP_003413167.1 NZ_CP041846:2864552-2864809 [Mycobacterium tuberculosis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Download         Length: 258 bp

>AT132803 NZ_CP041846:2864552-2864809 [Mycobacterium tuberculosis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ26

Antitoxin

Source ID Structure
AlphaFold DB A0A829C9W5

References