Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2824920..2825572 Replicon chromosome
Accession NZ_CP041844
Organism Mycobacterium tuberculosis strain 1-0160P6C4

Toxin (Protein)


Gene name vapC Uniprot ID G0TPX1
Locus tag FPJ64_RS13130 Protein ID WP_003412752.1
Coordinates 2825147..2825572 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ24
Locus tag FPJ64_RS13125 Protein ID WP_003412749.1
Coordinates 2824920..2825141 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ64_RS13110 2823160..2823366 - 207 WP_003899347.1 hypothetical protein -
FPJ64_RS13115 2823502..2824125 + 624 WP_003900858.1 TIGR00725 family protein -
FPJ64_RS13120 2824115..2824867 + 753 WP_003901416.1 hypothetical protein -
FPJ64_RS13125 2824920..2825141 + 222 WP_003412749.1 antitoxin Antitoxin
FPJ64_RS13130 2825147..2825572 + 426 WP_003412752.1 type II toxin-antitoxin system VapC family toxin Toxin
FPJ64_RS13135 2825595..2826776 - 1182 WP_003899351.1 2-oxo acid dehydrogenase subunit E2 -
FPJ64_RS13140 2826773..2827819 - 1047 WP_003412757.1 3-methyl-2-oxobutanoate dehydrogenase subunit beta -
FPJ64_RS13145 2827830..2828933 - 1104 WP_003412761.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
FPJ64_RS13150 2829192..2830013 - 822 WP_003412766.1 citrate (pro-3S)-lyase subunit beta -
FPJ64_RS13155 2830010..2830567 - 558 WP_003412768.1 MaoC family dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15392.89 Da        Isoelectric Point: 9.2386

>T132680 WP_003412752.1 NZ_CP041844:2825147-2825572 [Mycobacterium tuberculosis]
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRVSTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL

Download         Length: 426 bp

>T132680 NZ_CP041844:2825147-2825572 [Mycobacterium tuberculosis]
GTGGCGCTGCTCGACGTCAACGCATTGGTCGCGCTGGCGTGGGACTCACACATCCACCACGCCCGGATCCGCGAGTGGTT
TACCGCCAACGCCACGCTCGGCTGGGCGACTTGCCCGCTCACCGAAGCCGGCTTCGTGCGGGTGTCGACGAACCCAAAAG
TACTTCCCAGCGCGATCGGGATCGCAGACGCTCGACGGGTCCTCGTGGCACTACGCGCCGTGGGAGGCCACCGCTTCCTG
GCTGACGACGTATCGCTCGTCGATGACGATGTTCCGTTGATCGTCGGTTATCGCCAGGTGACCGACGCCCATCTGCTGAC
ACTCGCCCGCCGGCGCGGCGTCCGCCTGGTCACCTTCGACGCCGGTGTCTTCACCCTCGCCCAACAACGCCCCAAGACGC
CAGTGGAGCTGCTGACCATCCTCTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7864.93 Da        Isoelectric Point: 4.5258

>AT132680 WP_003412749.1 NZ_CP041844:2824920-2825141 [Mycobacterium tuberculosis]
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDED

Download         Length: 222 bp

>AT132680 NZ_CP041844:2824920-2825141 [Mycobacterium tuberculosis]
GTGCGAACGACACTTGACCTTGACGACGATGTGATCGCCGCGGCACGTGAACTTGCCTCCAGCCAGCGCCGCTCGCTCGG
CTCGGTGATTTCCGAACTCGCACGCCGTGGTCTCATGCCCGGACGCGTCGAGGCTGACGACGGGCTGCCGGTGATCCGCG
TTCCAGCCGGGACCCCGCCGATCACACCGGAGATGGTCCGTCGCGCGCTCGATGAGGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TPX1

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW03

References