Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 2213174..2213718 | Replicon | chromosome |
| Accession | NZ_CP041844 | ||
| Organism | Mycobacterium tuberculosis strain 1-0160P6C4 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | G0TLU9 |
| Locus tag | FPJ64_RS10245 | Protein ID | WP_003409896.1 |
| Coordinates | 2213174..2213470 (-) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P67299 |
| Locus tag | FPJ64_RS10250 | Protein ID | WP_003409899.1 |
| Coordinates | 2213467..2213718 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FPJ64_RS10190 | 2208207..2208557 | - | 351 | WP_003409871.1 | hypothetical protein | - |
| FPJ64_RS10195 | 2208568..2209470 | - | 903 | WP_003899097.1 | hypothetical protein | - |
| FPJ64_RS10200 | 2209491..2209682 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| FPJ64_RS10205 | 2209683..2209979 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| FPJ64_RS10210 | 2210219..2210434 | + | 216 | WP_193086104.1 | antitoxin | - |
| FPJ64_RS10215 | 2210431..2210742 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| FPJ64_RS10220 | 2210716..2211237 | - | 522 | WP_003904745.1 | hypothetical protein | - |
| FPJ64_RS10225 | 2211212..2211589 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | - |
| FPJ64_RS10230 | 2211631..2212080 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | - |
| FPJ64_RS10235 | 2212077..2212622 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| FPJ64_RS10240 | 2212511..2213125 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| FPJ64_RS10245 | 2213174..2213470 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| FPJ64_RS10250 | 2213467..2213718 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| FPJ64_RS10255 | 2213705..2214199 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| FPJ64_RS10260 | 2214359..2214766 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| FPJ64_RS10265 | 2214770..2215042 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| FPJ64_RS10270 | 2215075..2216295 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
| FPJ64_RS10275 | 2217194..2217991 | + | 798 | WP_003899101.1 | ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11268.64 Da Isoelectric Point: 6.8604
>T132671 WP_003409896.1 NZ_CP041844:c2213470-2213174 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
Download Length: 297 bp
>T132671 NZ_CP041844:c2213470-2213174 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9207.17 Da Isoelectric Point: 7.0150
>AT132671 WP_003409899.1 NZ_CP041844:c2213718-2213467 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
Download Length: 252 bp
>AT132671 NZ_CP041844:c2213718-2213467 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TLU9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BUZ2 |