Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 1394337..1394896 Replicon chromosome
Accession NZ_CP041844
Organism Mycobacterium tuberculosis strain 1-0160P6C4

Toxin (Protein)


Gene name relE Uniprot ID G0THS1
Locus tag FPJ64_RS06545 Protein ID WP_003898789.1
Coordinates 1394337..1394630 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0THS2
Locus tag FPJ64_RS06550 Protein ID WP_003406322.1
Coordinates 1394627..1394896 (-) Length 90 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ64_RS06520 1389931..1390191 + 261 WP_003406302.1 type II toxin-antitoxin system antitoxin VapB33 -
FPJ64_RS06525 1390188..1390619 + 432 WP_003406304.1 type II toxin-antitoxin system VapC family toxin -
FPJ64_RS06530 1390642..1392329 - 1688 Protein_1288 PE family protein -
FPJ64_RS06535 1392509..1393369 + 861 WP_003900301.1 hypothetical protein -
FPJ64_RS06540 1393450..1394280 - 831 WP_003898788.1 SDR family NAD(P)-dependent oxidoreductase -
FPJ64_RS06545 1394337..1394630 - 294 WP_003898789.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
FPJ64_RS06550 1394627..1394896 - 270 WP_003406322.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FPJ64_RS06555 1395009..1398704 - 3696 WP_003406323.1 multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit -
FPJ64_RS06560 1398846..1399634 - 789 WP_003406325.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 98 a.a.        Molecular weight: 11031.57 Da        Isoelectric Point: 9.6275

>T132662 WP_003898789.1 NZ_CP041844:c1394630-1394337 [Mycobacterium tuberculosis]
VSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEII
HIARRSASYRMNPCRPR

Download         Length: 294 bp

>T132662 NZ_CP041844:c1394630-1394337 [Mycobacterium tuberculosis]
GTGAGCGACGACCATCCCTACCACGTGGCGATCACCGCGACAGCGGCACGCGACCTGCAACGCTTACCCGAAAAGATCGC
CGCCGCATGTGTCGAGTTTGTTTTCGGACCGCTGCTTAACAACCCGCATAGGTTGGGCAAGCCGCTGCGCAATGACCTTG
AAGGCCTCCACTCAGCCCGCCGCGGTGATTACCGCGTCGTCTACGCCATCGACGACGGCCACCACCGAGTCGAGATCATC
CACATCGCTCGTCGCAGTGCCAGCTACCGAATGAACCCGTGCCGGCCACGTTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9766.97 Da        Isoelectric Point: 4.8615

>AT132662 WP_003406322.1 NZ_CP041844:c1394896-1394627 [Mycobacterium tuberculosis]
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSND
EIRNRYTAR

Download         Length: 270 bp

>AT132662 NZ_CP041844:c1394896-1394627 [Mycobacterium tuberculosis]
ATGGCTGTTGTCCCACTGGGCGAAGTCCGCAATCGCCTCTCTGAGTACGTCGCCGAAGTTGAGCTGACACACGAGCGCAT
CACGATAACCCGGCACGGTCATCCGGCGGCGGTATTGATCTCGGCCGATGACCTGGCGTCCATCGAGGAAACGCTGGAGG
TGCTACGCACCCCTGGCGCCAGCGAGGCCATTCGTGAAGGCCTCGCCGATGTTGCCGCAGGGCGCTTCGTGAGCAACGAC
GAGATCCGCAACCGTTACACCGCGCGGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G0THS1


Antitoxin

Source ID Structure
AlphaFold DB G0THS2

References