Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 699158..699804 Replicon chromosome
Accession NZ_CP041844
Organism Mycobacterium tuberculosis strain 1-0160P6C4

Toxin (Protein)


Gene name vapC Uniprot ID O07783
Locus tag FPJ64_RS03120 Protein ID WP_003403122.1
Coordinates 699158..699550 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ86
Locus tag FPJ64_RS03125 Protein ID WP_003403125.1
Coordinates 699547..699804 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ64_RS03105 694820..696346 + 1527 WP_003403112.1 virulence factor Mce family protein -
FPJ64_RS03110 696409..697551 + 1143 WP_003911253.1 virulence factor Mce family protein -
FPJ64_RS03115 697556..699106 + 1551 WP_003403119.1 MCE family protein -
FPJ64_RS03120 699158..699550 - 393 WP_003403122.1 type II toxin-antitoxin system toxin ribonuclease C4 Toxin
FPJ64_RS03125 699547..699804 - 258 WP_003403125.1 type II toxin-antitoxin system antitoxin VapB4 Antitoxin
FPJ64_RS03130 699987..701222 - 1236 WP_003403128.1 ATP-binding protein -
FPJ64_RS03135 701473..701886 - 414 WP_003403137.1 type II toxin-antitoxin system VapC family toxin -
FPJ64_RS03140 701883..702119 - 237 WP_003403139.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
FPJ64_RS03145 702223..702729 - 507 WP_003900973.1 two component system sensor kinase HK1 -
FPJ64_RS03150 702843..703373 - 531 WP_003917320.1 two component system sensor kinase HK2 -
FPJ64_RS03155 703357..704118 - 762 WP_003403148.1 two-component system response regulator TcrA -
FPJ64_RS03160 704175..704486 + 312 WP_003403164.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-122)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-53)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14080.08 Da        Isoelectric Point: 4.6558

>T132646 WP_003403122.1 NZ_CP041844:c699550-699158 [Mycobacterium tuberculosis]
VNVRRALADTSVFIGIEATRFDPDRFAGYEWGVSVVTLGELRLGVLQASGPEAAARRLSTYQLAQRFEPLGIDEAVSEAW
ALLVSKLRAAKLRVPINDSWIAATAVAHGIAILTQDNDYAAMPDVEVITI

Download         Length: 393 bp

>T132646 NZ_CP041844:c699550-699158 [Mycobacterium tuberculosis]
GTGAACGTACGGCGCGCCCTCGCCGACACATCCGTTTTCATTGGCATCGAGGCGACACGATTCGACCCGGACCGGTTTGC
GGGATACGAATGGGGCGTCTCGGTAGTCACACTCGGCGAGCTGCGGCTCGGGGTGTTGCAAGCCTCCGGCCCCGAGGCCG
CCGCACGTCGGCTCTCCACCTACCAGCTTGCGCAACGGTTCGAACCACTAGGCATCGACGAGGCGGTCTCCGAAGCATGG
GCATTACTGGTGTCCAAGCTGCGCGCCGCCAAACTGCGCGTGCCGATCAACGACAGCTGGATTGCGGCCACAGCCGTGGC
GCACGGCATTGCGATCCTGACCCAAGACAACGACTACGCCGCCATGCCCGACGTCGAGGTCATAACGATCTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9681.06 Da        Isoelectric Point: 7.0175

>AT132646 WP_003403125.1 NZ_CP041844:c699804-699547 [Mycobacterium tuberculosis]
MSATIPARDLRNHTAEVLRRVAAGEEIEVLKDNRPVARIVPLKRRRQWLPAAEVIGELVRLGPDTTNLGEELRETLTQTT
DDVRW

Download         Length: 258 bp

>AT132646 NZ_CP041844:c699804-699547 [Mycobacterium tuberculosis]
ATGTCTGCTACGATACCCGCTCGCGATCTTCGCAACCACACCGCCGAGGTACTGCGGCGAGTTGCCGCCGGCGAGGAAAT
CGAGGTGCTCAAGGACAATCGCCCCGTAGCGCGCATCGTTCCGCTCAAGCGGCGCCGCCAATGGTTGCCAGCTGCCGAGG
TGATCGGCGAACTGGTGCGCTTGGGCCCCGATACCACCAATCTGGGCGAGGAGCTGCGAGAGACGCTGACGCAAACCACG
GACGATGTGCGGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4F8V4

Antitoxin

Source ID Structure
AlphaFold DB G0TQ86

References