132609

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2188450..2189153 Replicon chromosome
Accession NZ_CP041843
Organism Mycobacterium tuberculosis strain 1-0168P6C4

Toxin (Protein)


Gene name mazF Uniprot ID G0TLK7
Locus tag FPJ65_RS10075 Protein ID WP_003409778.1
Coordinates 2188450..2188779 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TLK8
Locus tag FPJ65_RS10080 Protein ID WP_003409780.1
Coordinates 2188776..2189153 (-) Length 126 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ65_RS10055 2184833..2185903 + 1071 WP_003899091.1 epoxide hydrolase EphB -
FPJ65_RS10060 2185900..2186415 + 516 WP_003409718.1 flavin reductase family protein -
FPJ65_RS10065 2186412..2187473 + 1062 WP_003899092.1 3,4-dihydroxy-2-butanone-4-phosphate synthase -
FPJ65_RS10070 2187470..2188240 + 771 WP_003409775.1 SDR family oxidoreductase -
FPJ65_RS10075 2188450..2188779 - 330 WP_003409778.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
FPJ65_RS10080 2188776..2189153 - 378 WP_003409780.1 type II toxin-antitoxin system antitoxin MazE5 Antitoxin
FPJ65_RS10085 2189150..2189740 - 591 WP_003409784.1 SEC-C domain-containing protein -
FPJ65_RS10090 2189795..2191159 + 1365 WP_014585532.1 HNH endonuclease -
FPJ65_RS10095 2191314..2191766 - 453 WP_003899095.1 lipoprotein -
FPJ65_RS10100 2191830..2192231 + 402 WP_003409869.1 hypothetical protein -
FPJ65_RS10105 2192224..2192406 - 183 WP_003409870.1 hypothetical protein -
FPJ65_RS10110 2192520..2192870 - 351 WP_003899096.1 hypothetical protein -
FPJ65_RS10115 2192881..2193783 - 903 WP_003899097.1 hypothetical protein -
FPJ65_RS10120 2193804..2193995 - 192 WP_003409876.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(7-103)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 110 a.a.        Molecular weight: 11787.82 Da        Isoelectric Point: 8.5361

>T132609 WP_003409778.1 NZ_CP041843:c2188779-2188450 [Mycobacterium tuberculosis]
VTALPARGEVWWCEMAEIGRRPVVVLSRDAAIPRLRRALVAPCTTTIRGLASEVVLEPGSDPIPRRSAVNLDSVESVSVA
VLVNRLGRLADIRMRAICTALEVAVDCSR

Download         Length: 330 bp

>T132609 NZ_CP041843:c2188779-2188450 [Mycobacterium tuberculosis]
GTGACCGCACTTCCGGCGCGCGGAGAGGTGTGGTGGTGTGAGATGGCTGAGATCGGTCGGCGACCAGTCGTCGTGCTGTC
GCGCGATGCCGCGATCCCTCGGCTGCGACGCGCACTTGTCGCGCCCTGCACCACGACCATCCGAGGGCTAGCCAGTGAGG
TTGTTCTTGAACCCGGTTCCGACCCGATCCCGCGCCGTTCCGCGGTGAATTTGGACTCAGTCGAAAGTGTCTCGGTCGCG
GTATTGGTGAATCGGCTTGGCCGCCTCGCCGACATCCGGATGCGCGCCATCTGCACGGCCCTCGAGGTCGCCGTCGATTG
CTCTCGATGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13560.07 Da        Isoelectric Point: 5.1519

>AT132609 WP_003409780.1 NZ_CP041843:c2189153-2188776 [Mycobacterium tuberculosis]
VKTARLQVTLRCAVDLINSSSDQCFARIEHVASDQADPRPGVWHSSGMNRIRLSTTVDAALLTSARDMRAGITDAALIDE
ALAALLARHRSAEVDASYAAYDKHPVDEPDEWGDLASWRRAAGDS

Download         Length: 378 bp

>AT132609 NZ_CP041843:c2189153-2188776 [Mycobacterium tuberculosis]
GTGAAGACGGCCCGGTTGCAGGTGACGTTGCGCTGCGCGGTAGACCTCATCAATTCGTCCAGCGACCAATGTTTCGCCCG
TATCGAGCACGTTGCGTCCGATCAGGCGGATCCACGCCCCGGAGTGTGGCATAGTAGTGGCATGAATCGCATACGGCTGA
GCACTACTGTCGACGCCGCACTCTTGACAAGTGCGCGCGACATGCGGGCAGGAATCACTGACGCAGCCCTCATCGATGAG
GCCCTTGCGGCATTACTGGCTCGTCATCGATCGGCCGAGGTGGATGCCAGCTATGCGGCCTACGACAAGCACCCGGTCGA
TGAGCCCGACGAGTGGGGCGATCTAGCGTCGTGGCGGCGGGCGGCTGGAGACTCGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G0TLK7


Antitoxin

Source ID Structure
AlphaFold DB G0TLK8

References