Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 709163..709788 Replicon chromosome
Accession NZ_CP041842
Organism Mycobacterium tuberculosis strain 2-0013P6C4

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag FPJ66_RS03215 Protein ID WP_003403218.1
Coordinates 709387..709788 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag FPJ66_RS03210 Protein ID WP_003403213.1
Coordinates 709163..709390 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ66_RS03185 704342..704563 - 222 WP_003898525.1 DUF4926 domain-containing protein -
FPJ66_RS03190 704705..705310 + 606 WP_003898526.1 hypothetical protein -
FPJ66_RS03195 705329..707896 - 2568 WP_003901879.1 SEC-C domain-containing protein -
FPJ66_RS03200 707980..708729 + 750 WP_003898528.1 hypothetical protein -
FPJ66_RS03205 708726..708968 + 243 WP_003403210.1 hypothetical protein -
FPJ66_RS03210 709163..709390 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
FPJ66_RS03215 709387..709788 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
FPJ66_RS03220 709917..710612 + 696 WP_003900189.1 galactose-1-phosphate uridylyltransferase -
FPJ66_RS03225 710609..711100 + 492 WP_003905354.1 galactose-1-phosphate uridylyltransferase -
FPJ66_RS03230 711097..712188 + 1092 WP_003900977.1 galactokinase -
FPJ66_RS03235 712583..713647 + 1065 WP_003898532.1 hypothetical protein -
FPJ66_RS03240 713751..714698 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T132528 WP_003403218.1 NZ_CP041842:709387-709788 [Mycobacterium tuberculosis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T132528 NZ_CP041842:709387-709788 [Mycobacterium tuberculosis]
GTGACGGTGCTGCTCGACGCCAACGTGCTGATCGCATTGGTGGTCGCCGAGCATGTGCATCATGATGCCGCAGCGGACTG
GCTCATGGCGTCCGACACCGGATTTGCGACCTGCCCGATGACACAAGGAAGCCTGGTTCGATTCCTGGTGCGCTCGGGAC
AGTCCGCGGCGGCGGCTCGGGATGTCGTCAGTGCGGTCCAGTGCACGAGCCGCCACGAATTCTGGCCCGATGCACTCTCT
TTCGCCGGTGTCGAGGTCGCTGGTGTGGTTGGGCACCGGCAGGTGACCGATGCCTACCTTGCCCAGCTCGCGCGAAGCCA
CGACGGGCAGTTGGCGACGCTCGACAGCGGCTTAGCACACCTGCACGGCGACGTCGCGGTACTCATTCCAACGACCACCT
GA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT132528 WP_003403213.1 NZ_CP041842:709163-709390 [Mycobacterium tuberculosis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT132528 NZ_CP041842:709163-709390 [Mycobacterium tuberculosis]
GTGCGCACTACCATCGACCTGCCGCAAGACCTGCACAAGCAGGCACTGGCGATTGCCCGGGATACGCACCGCACGTTGAG
TGAAACGGTCGCCGACCTCATGCGACGAGGCCTGGCCGCCAACCGCCCTACCGCGTTGTCCTCAGACCCCAGAACGGGAT
TGCCTTTGGTGAGCGTCGGGACCGTCGTGACCTCCGAGGACGTGCGTTCATTAGAGGACGAGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References