Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 1394150..1394709 Replicon chromosome
Accession NZ_CP041841
Organism Mycobacterium tuberculosis strain 2-0021P6C4

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag FPJ67_RS06550 Protein ID WP_031712129.1
Coordinates 1394150..1394443 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0THS2
Locus tag FPJ67_RS06555 Protein ID WP_003406322.1
Coordinates 1394440..1394709 (-) Length 90 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ67_RS06525 1389743..1390003 + 261 WP_003406302.1 type II toxin-antitoxin system antitoxin VapB33 -
FPJ67_RS06530 1390000..1390431 + 432 WP_003406304.1 type II toxin-antitoxin system VapC family toxin -
FPJ67_RS06535 1390454..1392142 - 1689 WP_003910308.1 PE family protein -
FPJ67_RS06540 1392322..1393182 + 861 WP_003900301.1 hypothetical protein -
FPJ67_RS06545 1393263..1394093 - 831 WP_003898788.1 SDR family NAD(P)-dependent oxidoreductase -
FPJ67_RS06550 1394150..1394443 - 294 WP_031712129.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
FPJ67_RS06555 1394440..1394709 - 270 WP_003406322.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FPJ67_RS06560 1394822..1398517 - 3696 WP_003898790.1 multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit -
FPJ67_RS06565 1398659..1399447 - 789 WP_003406325.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 98 a.a.        Molecular weight: 11030.63 Da        Isoelectric Point: 9.6275

>T132481 WP_031712129.1 NZ_CP041841:c1394443-1394150 [Mycobacterium tuberculosis]
VSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRIDLEGLHSARRGDYRVVYAIDDGHHRVEII
HIARRSASYRMNPCRPR

Download         Length: 294 bp

>T132481 NZ_CP041841:c1394443-1394150 [Mycobacterium tuberculosis]
GTGAGCGACGACCATCCCTACCACGTGGCGATCACCGCGACAGCGGCACGCGACCTGCAACGCTTACCCGAAAAGATCGC
CGCCGCATGTGTCGAGTTTGTTTTCGGACCGCTGCTTAACAACCCGCATAGGTTGGGCAAGCCGCTGCGCATTGACCTTG
AAGGCCTCCACTCAGCCCGCCGCGGTGATTACCGCGTCGTCTACGCCATCGACGACGGCCACCACCGAGTCGAGATCATC
CACATCGCTCGTCGCAGTGCCAGCTACCGAATGAACCCGTGCCGGCCACGTTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9766.97 Da        Isoelectric Point: 4.8615

>AT132481 WP_003406322.1 NZ_CP041841:c1394709-1394440 [Mycobacterium tuberculosis]
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSND
EIRNRYTAR

Download         Length: 270 bp

>AT132481 NZ_CP041841:c1394709-1394440 [Mycobacterium tuberculosis]
ATGGCTGTTGTCCCACTGGGCGAAGTCCGCAATCGCCTCTCTGAGTACGTCGCCGAAGTTGAGCTGACACACGAGCGCAT
CACGATAACCCGGCACGGTCATCCGGCGGCGGTATTGATCTCGGCCGATGACCTGGCGTCCATCGAGGAAACGCTGGAGG
TGCTACGCACCCCTGGCGCCAGCGAGGCCATTCGTGAAGGCCTCGCCGATGTTGCCGCAGGGCGCTTCGTGAGCAACGAC
GAGATCCGCAACCGTTACACCGCGCGGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB G0THS2

References