Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1244879..1245447 Replicon chromosome
Accession NZ_CP041841
Organism Mycobacterium tuberculosis strain 2-0021P6C4

Toxin (Protein)


Gene name vapC Uniprot ID G0TH08
Locus tag FPJ67_RS05885 Protein ID WP_003405865.1
Coordinates 1245073..1245447 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TH07
Locus tag FPJ67_RS05880 Protein ID WP_003405863.1
Coordinates 1244879..1245076 (+) Length 66 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ67_RS05860 1240920..1241558 - 639 WP_003898730.1 lipid droplet-associated protein -
FPJ67_RS05865 1241648..1242655 + 1008 WP_003405853.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
FPJ67_RS05870 1242672..1243655 - 984 WP_003898731.1 hypothetical protein -
FPJ67_RS05875 1243718..1244791 + 1074 WP_003898732.1 redox-regulated ATPase YchF -
FPJ67_RS05880 1244879..1245076 + 198 WP_003405863.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
FPJ67_RS05885 1245073..1245447 + 375 WP_003405865.1 type II toxin-antitoxin system VapC family toxin Toxin
FPJ67_RS05890 1245650..1246348 + 699 WP_003898733.1 hypothetical protein -
FPJ67_RS05895 1246466..1246651 + 186 WP_003901093.1 hypothetical protein -
FPJ67_RS05900 1246578..1246853 - 276 WP_003405867.1 hypothetical protein -
FPJ67_RS05905 1247096..1247419 + 324 WP_003405871.1 antibiotic biosynthesis monooxygenase -
FPJ67_RS05910 1247434..1248144 - 711 WP_003911399.1 hypothetical protein -
FPJ67_RS05915 1248166..1248375 + 210 WP_003911400.1 hypothetical protein -
FPJ67_RS05920 1248327..1249034 - 708 Protein_1166 adenylate/guanylate cyclase domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-111)

Antitoxin

(1-42)


Sequences


Toxin        


Download         Length: 125 a.a.        Molecular weight: 13444.56 Da        Isoelectric Point: 5.1881

>T132479 WP_003405865.1 NZ_CP041841:1245073-1245447 [Mycobacterium tuberculosis]
VILVDTSVWIEHLRAADARLVELLGDDEAGCHPLVIEELALGSIKQRDVVLDLLANLYQFPVVTHDEVLRLVGRRRLWGR
GLGAVDANLLGSVALVGGARLWTRDKRLKAACAESGVALAEEVS

Download         Length: 375 bp

>T132479 NZ_CP041841:1245073-1245447 [Mycobacterium tuberculosis]
GTGATCCTGGTCGACACTTCGGTATGGATTGAGCACCTGCGCGCCGCCGACGCGCGACTCGTCGAGCTGCTGGGCGATGA
CGAGGCCGGTTGCCATCCGCTCGTCATCGAGGAGCTGGCGCTTGGCTCGATCAAGCAGCGAGACGTTGTTCTCGATCTGT
TGGCCAACCTCTACCAGTTTCCGGTGGTGACCCACGACGAAGTGTTGCGGCTTGTCGGTCGGCGGCGGTTGTGGGGTCGG
GGACTCGGTGCCGTCGATGCCAACCTTCTTGGTTCGGTGGCTCTGGTTGGCGGCGCGCGACTATGGACGCGGGACAAGCG
GTTGAAGGCGGCGTGCGCGGAAAGCGGTGTTGCGCTGGCTGAGGAAGTGTCCTGA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 6973.03 Da        Isoelectric Point: 11.7327

>AT132479 WP_003405863.1 NZ_CP041841:1244879-1245076 [Mycobacterium tuberculosis]
MRTTVTVDDALLAKAAELTGVKEKSTLLREGLQTLVRVESARRLAALGGTDPQATAAPRRRTSPR

Download         Length: 198 bp

>AT132479 NZ_CP041841:1244879-1245076 [Mycobacterium tuberculosis]
ATGAGGACGACGGTGACCGTTGACGACGCCTTGTTAGCCAAAGCGGCCGAATTGACTGGGGTGAAAGAGAAGTCGACGCT
CCTGCGCGAGGGGTTGCAGACACTGGTCCGGGTGGAGAGCGCCCGGCGGTTGGCGGCTCTCGGCGGCACCGACCCGCAAG
CTACCGCGGCGCCGAGACGCCGGACGTCGCCCCGGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G0TH08


Antitoxin

Source ID Structure
AlphaFold DB G0TH07

References