Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC-VapB |
Location | 756891..757524 | Replicon | chromosome |
Accession | NZ_CP041841 | ||
Organism | Mycobacterium tuberculosis strain 2-0021P6C4 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | G0TQD6 |
Locus tag | FPJ67_RS03465 | Protein ID | WP_003403365.1 |
Coordinates | 756891..757274 (-) | Length | 128 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | A0A655G1G4 |
Locus tag | FPJ67_RS03470 | Protein ID | WP_031582830.1 |
Coordinates | 757369..757524 (-) | Length | 52 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
FPJ67_RS03440 | 752182..752718 | + | 537 | WP_003403341.1 | 50S ribosomal protein L10 | - |
FPJ67_RS03445 | 752755..753147 | + | 393 | WP_003403353.1 | 50S ribosomal protein L7/L12 | - |
FPJ67_RS03450 | 753140..753835 | - | 696 | WP_003403355.1 | TetR/AcrR family transcriptional regulator | - |
FPJ67_RS03455 | 753906..755412 | + | 1507 | Protein_682 | carotenoid cleavage oxygenase | - |
FPJ67_RS03460 | 755493..756503 | + | 1011 | WP_003911248.1 | ABC transporter ATP-binding protein | - |
FPJ67_RS03465 | 756891..757274 | - | 384 | WP_003403365.1 | ribonuclease VapC6 | Toxin |
FPJ67_RS03470 | 757369..757524 | - | 156 | WP_031582830.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
FPJ67_RS03475 | 757600..758316 | - | 717 | WP_003403371.1 | CPBP family intramembrane metalloprotease | - |
FPJ67_RS03480 | 758592..758900 | - | 309 | WP_003403376.1 | type II toxin-antitoxin system PemK/MazF family toxin | - |
FPJ67_RS03485 | 758887..759132 | - | 246 | WP_003403381.1 | ribbon-helix-helix protein, CopG family | - |
FPJ67_RS03490 | 759242..759679 | - | 438 | WP_003403386.1 | type II toxin-antitoxin system VapC family toxin | - |
FPJ67_RS03495 | 759676..759930 | - | 255 | WP_003911263.1 | antitoxin VapB7 | - |
FPJ67_RS03500 | 760044..762407 | + | 2364 | WP_031582834.1 | arylsulfatase AtsD | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 128 a.a. Molecular weight: 13959.73 Da Isoelectric Point: 6.0803
>T132470 WP_003403365.1 NZ_CP041841:c757274-756891 [Mycobacterium tuberculosis]
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD
Download Length: 384 bp
>T132470 NZ_CP041841:c757274-756891 [Mycobacterium tuberculosis]
TTGGCGGCTGCAACGACAACCGGAACCCACCGAGGCCTGGAACTCCGCGCTGCTCAGCGGGCCGTCGGGTCGTGCGAACC
GCAACGAGCCGAGTTCTGCCGATCAGCGCGGAATGCGGACGAGTTCGACCAGATGAGCCGGATGTTTGGTGACGTCTACC
CCGATGTGCCAGTGCCGAAATCCGTGTGGCGGTGGATCGATTCGGCACAGCACCGCCTCGCCCGGGCGGGAGCGGTGGGT
GCCCTGTCGGTTGTCGATCTGCTGATCTGCGACACTGCGGCGGCCAGGGGCCTAGTAGTCCTCCACGACGATGCCGACTA
CGAACTCGCAGAGCGTCACCTTCCCGACATCAGAGTGCGGAGGGTCGTCAGCGCCGACGACTAG
TTGGCGGCTGCAACGACAACCGGAACCCACCGAGGCCTGGAACTCCGCGCTGCTCAGCGGGCCGTCGGGTCGTGCGAACC
GCAACGAGCCGAGTTCTGCCGATCAGCGCGGAATGCGGACGAGTTCGACCAGATGAGCCGGATGTTTGGTGACGTCTACC
CCGATGTGCCAGTGCCGAAATCCGTGTGGCGGTGGATCGATTCGGCACAGCACCGCCTCGCCCGGGCGGGAGCGGTGGGT
GCCCTGTCGGTTGTCGATCTGCTGATCTGCGACACTGCGGCGGCCAGGGGCCTAGTAGTCCTCCACGACGATGCCGACTA
CGAACTCGCAGAGCGTCACCTTCCCGACATCAGAGTGCGGAGGGTCGTCAGCGCCGACGACTAG
Antitoxin
Download Length: 52 a.a. Molecular weight: 5860.66 Da Isoelectric Point: 5.7734
>AT132470 WP_031582830.1 NZ_CP041841:c757524-757369 [Mycobacterium tuberculosis]
VSVTQIDLDDEALADVMRTAAVHTKKEAVNLAMRDYVERFRRIEALARSRE
VSVTQIDLDDEALADVMRTAAVHTKKEAVNLAMRDYVERFRRIEALARSRE
Download Length: 156 bp
>AT132470 NZ_CP041841:c757524-757369 [Mycobacterium tuberculosis]
GTGTCGGTGACCCAGATCGACCTCGACGACGAAGCGCTGGCCGATGTGATGCGCACCGCCGCCGTGCACACAAAGAAGGA
AGCCGTGAACCTCGCGATGCGCGATTACGTCGAACGGTTTCGGCGCATCGAGGCCCTGGCCCGCTCGCGCGAGTAG
GTGTCGGTGACCCAGATCGACCTCGACGACGAAGCGCTGGCCGATGTGATGCGCACCGCCGCCGTGCACACAAAGAAGGA
AGCCGTGAACCTCGCGATGCGCGATTACGTCGAACGGTTTCGGCGCATCGAGGCCCTGGCCCGCTCGCGCGAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | G0TQD6 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A655G1G4 |