Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 714155..714780 Replicon chromosome
Accession NZ_CP041841
Organism Mycobacterium tuberculosis strain 2-0021P6C4

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag FPJ67_RS03245 Protein ID WP_003403218.1
Coordinates 714379..714780 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag FPJ67_RS03240 Protein ID WP_003403213.1
Coordinates 714155..714382 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ67_RS03215 709334..709555 - 222 WP_003898525.1 DUF4926 domain-containing protein -
FPJ67_RS03220 709697..710302 + 606 WP_003898526.1 hypothetical protein -
FPJ67_RS03225 710321..712888 - 2568 WP_003900188.1 SEC-C domain-containing protein -
FPJ67_RS03230 712972..713721 + 750 WP_003898528.1 hypothetical protein -
FPJ67_RS03235 713718..713960 + 243 WP_003403210.1 hypothetical protein -
FPJ67_RS03240 714155..714382 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
FPJ67_RS03245 714379..714780 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
FPJ67_RS03250 714909..715604 + 696 WP_003900189.1 galactose-1-phosphate uridylyltransferase -
FPJ67_RS03255 715601..716092 + 492 WP_003905354.1 galactose-1-phosphate uridylyltransferase -
FPJ67_RS03260 716089..717180 + 1092 WP_003906403.1 galactokinase -
FPJ67_RS03265 717575..718639 + 1065 WP_003898532.1 hypothetical protein -
FPJ67_RS03270 718743..719690 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T132467 WP_003403218.1 NZ_CP041841:714379-714780 [Mycobacterium tuberculosis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T132467 NZ_CP041841:714379-714780 [Mycobacterium tuberculosis]
GTGACGGTGCTGCTCGACGCCAACGTGCTGATCGCATTGGTGGTCGCCGAGCATGTGCATCATGATGCCGCAGCGGACTG
GCTCATGGCGTCCGACACCGGATTTGCGACCTGCCCGATGACACAAGGAAGCCTGGTTCGATTCCTGGTGCGCTCGGGAC
AGTCCGCGGCGGCGGCTCGGGATGTCGTCAGTGCGGTCCAGTGCACGAGCCGCCACGAATTCTGGCCCGATGCACTCTCT
TTCGCCGGTGTCGAGGTCGCTGGTGTGGTTGGGCACCGGCAGGTGACCGATGCCTACCTTGCCCAGCTCGCGCGAAGCCA
CGACGGGCAGTTGGCGACGCTCGACAGCGGCTTAGCACACCTGCACGGCGACGTCGCGGTACTCATTCCAACGACCACCT
GA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT132467 WP_003403213.1 NZ_CP041841:714155-714382 [Mycobacterium tuberculosis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT132467 NZ_CP041841:714155-714382 [Mycobacterium tuberculosis]
GTGCGCACTACCATCGACCTGCCGCAAGACCTGCACAAGCAGGCACTGGCGATTGCCCGGGATACGCACCGCACGTTGAG
TGAAACGGTCGCCGACCTCATGCGACGAGGCCTGGCCGCCAACCGCCCTACCGCGTTGTCCTCAGACCCCAGAACGGGAT
TGCCTTTGGTGAGCGTCGGGACCGTCGTGACCTCCGAGGACGTGCGTTCATTAGAGGACGAGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References