132440

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2881623..2882332 Replicon chromosome
Accession NZ_CP041840
Organism Mycobacterium tuberculosis strain 2-0022P6C4

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ26
Locus tag FPJ68_RS13340 Protein ID WP_003413164.1
Coordinates 2881623..2882036 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P95006
Locus tag FPJ68_RS13345 Protein ID WP_003413167.1
Coordinates 2882075..2882332 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ68_RS13310 2877333..2877647 + 315 WP_009937839.1 hypothetical protein -
FPJ68_RS13315 2877943..2879154 + 1212 WP_003900845.1 alpha/beta hydrolase family protein -
FPJ68_RS13320 2879281..2879940 + 660 WP_003900846.1 LppA family lipoprotein -
FPJ68_RS13325 2879937..2880596 + 660 WP_193042886.1 hypothetical protein -
FPJ68_RS13330 2880593..2881255 + 663 WP_031712310.1 hypothetical protein -
FPJ68_RS13335 2881252..2881530 + 279 WP_003901422.1 type II toxin-antitoxin system VapB family antitoxin -
FPJ68_RS13340 2881623..2882036 + 414 WP_003413164.1 PIN domain nuclease Toxin
FPJ68_RS13345 2882075..2882332 + 258 WP_003413167.1 ribbon-helix-helix domain-containing protein Antitoxin
FPJ68_RS13350 2882329..2882706 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
FPJ68_RS13355 2882722..2883096 - 375 WP_003413177.1 hypothetical protein -
FPJ68_RS13360 2883196..2883591 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 -
FPJ68_RS13365 2883588..2883833 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 -
FPJ68_RS13370 2884244..2884663 - 420 WP_003413190.1 A24 family peptidase -
FPJ68_RS13375 2884675..2885484 - 810 WP_003413193.1 shikimate dehydrogenase -
FPJ68_RS13380 2885481..2886734 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
FPJ68_RS13385 2886727..2887239 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15045.00 Da        Isoelectric Point: 5.4673

>T132440 WP_003413164.1 NZ_CP041840:2881623-2882036 [Mycobacterium tuberculosis]
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL

Download         Length: 414 bp

>T132440 NZ_CP041840:2881623-2882036 [Mycobacterium tuberculosis]
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9453.63 Da        Isoelectric Point: 10.6555

>AT132440 WP_003413167.1 NZ_CP041840:2882075-2882332 [Mycobacterium tuberculosis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Download         Length: 258 bp

>AT132440 NZ_CP041840:2882075-2882332 [Mycobacterium tuberculosis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ26

Antitoxin

Source ID Structure
AlphaFold DB A0A829C9W5

References