Detailed information of TA system TA132420

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 1394226..1394785
• Replicon: chromosome
• Accession: NZ_CP041840
• Organism: Mycobacterium tuberculosis strain 2-0022P6C4

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FPJ68_RS06540
• Protein ID: WP_031712129.1
• Coordinates: 1394226..1394519 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G0THS2
• Locus tag: FPJ68_RS06545
• Protein ID: WP_003406322.1
• Coordinates: 1394516..1394785 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPJ68_RS06515	1389819..1390079	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	-
FPJ68_RS06520	1390076..1390507	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	-
FPJ68_RS06525	1390530..1392218	-	1689	WP_003910308.1	PE family protein	-
FPJ68_RS06530	1392398..1393258	+	861	WP_003900301.1	hypothetical protein	-
FPJ68_RS06535	1393339..1394169	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
FPJ68_RS06540	1394226..1394519	-	294	WP_031712129.1	type II toxin-antitoxin system mRNA interferase RelE	Toxin
FPJ68_RS06545	1394516..1394785	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FPJ68_RS06550	1394898..1398593	-	3696	WP_003898790.1	multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit	-
FPJ68_RS06555	1398735..1399523	-	789	WP_003406325.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (9-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11030.63 Da
• Isoelectric Point: 9.6275

>T132420 WP_031712129.1 NZ_CP041840:c1394519-1394226 [Mycobacterium tuberculosis]
VSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRIDLEGLHSARRGDYRVVYAIDDGHHRVEII
HIARRSASYRMNPCRPR

Nucleotide

• Length: 294 bp

>T132420 NZ_CP041840:c1394519-1394226 [Mycobacterium tuberculosis]
GTGAGCGACGACCATCCCTACCACGTGGCGATCACCGCGACAGCGGCACGCGACCTGCAACGCTTACCCGAAAAGATCGC
CGCCGCATGTGTCGAGTTTGTTTTCGGACCGCTGCTTAACAACCCGCATAGGTTGGGCAAGCCGCTGCGCATTGACCTTG
AAGGCCTCCACTCAGCCCGCCGCGGTGATTACCGCGTCGTCTACGCCATCGACGACGGCCACCACCGAGTCGAGATCATC
CACATCGCTCGTCGCAGTGCCAGCTACCGAATGAACCCGTGCCGGCCACGTTAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9766.97 Da
• Isoelectric Point: 4.8615

>AT132420 WP_003406322.1 NZ_CP041840:c1394785-1394516 [Mycobacterium tuberculosis]
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSND
EIRNRYTAR

Nucleotide

• Length: 270 bp

>AT132420 NZ_CP041840:c1394785-1394516 [Mycobacterium tuberculosis]
ATGGCTGTTGTCCCACTGGGCGAAGTCCGCAATCGCCTCTCTGAGTACGTCGCCGAAGTTGAGCTGACACACGAGCGCAT
CACGATAACCCGGCACGGTCATCCGGCGGCGGTATTGATCTCGGCCGATGACCTGGCGTCCATCGAGGAAACGCTGGAGG
TGCTACGCACCCCTGGCGCCAGCGAGGCCATTCGTGAAGGCCTCGCCGATGTTGCCGCAGGGCGCTTCGTGAGCAACGAC
GAGATCCGCAACCGTTACACCGCGCGGTGA

Structures

Antitoxin

• AlphaFold DB: G0THS2