Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3723082..3723756 Replicon chromosome
Accession NZ_CP041838
Organism Mycobacterium tuberculosis strain 2-0028P6C4

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag FPJ70_RS17425 Protein ID WP_003417282.1
Coordinates 3723082..3723510 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag FPJ70_RS17430 Protein ID WP_003417286.1
Coordinates 3723514..3723756 (-) Length 81 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ70_RS17400 3718904..3719305 - 402 WP_003417264.1 cytidine deaminase -
FPJ70_RS17405 3719446..3719880 + 435 WP_003900017.1 succinate dehydrogenase, cytochrome b556 subunit -
FPJ70_RS17410 3719877..3720311 + 435 WP_003417269.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
FPJ70_RS17415 3720440..3722212 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
FPJ70_RS17420 3722212..3723003 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
FPJ70_RS17425 3723082..3723510 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
FPJ70_RS17430 3723514..3723756 - 243 WP_003417286.1 ribbon-helix-helix domain-containing protein Antitoxin
FPJ70_RS17435 3723878..3724492 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
FPJ70_RS17440 3724489..3725154 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
FPJ70_RS17445 3725155..3725688 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
FPJ70_RS17450 3725685..3726059 - 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -
FPJ70_RS17455 3726156..3727220 - 1065 WP_003913037.1 GTP 3',8-cyclase MoaA -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-141)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T132331 WP_003417282.1 NZ_CP041838:c3723510-3723082 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T132331 NZ_CP041838:c3723510-3723082 [Mycobacterium tuberculosis]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT132331 WP_003417286.1 NZ_CP041838:c3723756-3723514 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT132331 NZ_CP041838:c3723756-3723514 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0


Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References