Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 756886..757519 Replicon chromosome
Accession NZ_CP041838
Organism Mycobacterium tuberculosis strain 2-0028P6C4

Toxin (Protein)


Gene name vapC Uniprot ID G0TQD6
Locus tag FPJ70_RS03465 Protein ID WP_003403365.1
Coordinates 756886..757269 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A655G1G4
Locus tag FPJ70_RS03470 Protein ID WP_031582830.1
Coordinates 757364..757519 (-) Length 52 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ70_RS03440 752177..752713 + 537 WP_003403341.1 50S ribosomal protein L10 -
FPJ70_RS03445 752750..753142 + 393 WP_003403353.1 50S ribosomal protein L7/L12 -
FPJ70_RS03450 753135..753830 - 696 WP_003403355.1 TetR/AcrR family transcriptional regulator -
FPJ70_RS03455 753901..755407 + 1507 Protein_682 carotenoid cleavage oxygenase -
FPJ70_RS03460 755488..756498 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
FPJ70_RS03465 756886..757269 - 384 WP_003403365.1 ribonuclease VapC6 Toxin
FPJ70_RS03470 757364..757519 - 156 WP_031582830.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
FPJ70_RS03475 757595..758311 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
FPJ70_RS03480 758587..758895 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
FPJ70_RS03485 758882..759127 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
FPJ70_RS03490 759237..759674 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin -
FPJ70_RS03495 759671..759925 - 255 WP_003911263.1 antitoxin VapB7 -
FPJ70_RS03500 760039..762402 + 2364 WP_031582834.1 arylsulfatase AtsD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-44)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13959.73 Da        Isoelectric Point: 6.0803

>T132287 WP_003403365.1 NZ_CP041838:c757269-756886 [Mycobacterium tuberculosis]
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD

Download         Length: 384 bp

>T132287 NZ_CP041838:c757269-756886 [Mycobacterium tuberculosis]
TTGGCGGCTGCAACGACAACCGGAACCCACCGAGGCCTGGAACTCCGCGCTGCTCAGCGGGCCGTCGGGTCGTGCGAACC
GCAACGAGCCGAGTTCTGCCGATCAGCGCGGAATGCGGACGAGTTCGACCAGATGAGCCGGATGTTTGGTGACGTCTACC
CCGATGTGCCAGTGCCGAAATCCGTGTGGCGGTGGATCGATTCGGCACAGCACCGCCTCGCCCGGGCGGGAGCGGTGGGT
GCCCTGTCGGTTGTCGATCTGCTGATCTGCGACACTGCGGCGGCCAGGGGCCTAGTAGTCCTCCACGACGATGCCGACTA
CGAACTCGCAGAGCGTCACCTTCCCGACATCAGAGTGCGGAGGGTCGTCAGCGCCGACGACTAG

Antitoxin


Download         Length: 52 a.a.        Molecular weight: 5860.66 Da        Isoelectric Point: 5.7734

>AT132287 WP_031582830.1 NZ_CP041838:c757519-757364 [Mycobacterium tuberculosis]
VSVTQIDLDDEALADVMRTAAVHTKKEAVNLAMRDYVERFRRIEALARSRE

Download         Length: 156 bp

>AT132287 NZ_CP041838:c757519-757364 [Mycobacterium tuberculosis]
GTGTCGGTGACCCAGATCGACCTCGACGACGAAGCGCTGGCCGATGTGATGCGCACCGCCGCCGTGCACACAAAGAAGGA
AGCCGTGAACCTCGCGATGCGCGATTACGTCGAACGGTTTCGGCGCATCGAGGCCCTGGCCCGCTCGCGCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQD6

Antitoxin

Source ID Structure
AlphaFold DB A0A655G1G4

References