Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2210002..2210546 Replicon chromosome
Accession NZ_CP041837
Organism Mycobacterium tuberculosis strain 2-0029P6C4

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag FPJ71_RS10195 Protein ID WP_003409896.1
Coordinates 2210002..2210298 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag FPJ71_RS10200 Protein ID WP_003409899.1
Coordinates 2210295..2210546 (-) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ71_RS10140 2205035..2205385 - 351 WP_003899096.1 hypothetical protein -
FPJ71_RS10145 2205396..2206298 - 903 WP_003899097.1 hypothetical protein -
FPJ71_RS10150 2206319..2206510 - 192 WP_003409876.1 hypothetical protein -
FPJ71_RS10155 2206511..2206807 - 297 WP_003409877.1 hypothetical protein -
FPJ71_RS10160 2207047..2207262 + 216 WP_003409878.1 antitoxin -
FPJ71_RS10165 2207259..2207570 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
FPJ71_RS10170 2207544..2208065 - 522 WP_003904745.1 hypothetical protein -
FPJ71_RS10175 2208040..2208417 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB -
FPJ71_RS10180 2208459..2208908 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA -
FPJ71_RS10185 2208905..2209450 + 546 WP_003409891.1 SecB-like chaperone -
FPJ71_RS10190 2209339..2209953 - 615 WP_003901296.1 hypothetical protein -
FPJ71_RS10195 2210002..2210298 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FPJ71_RS10200 2210295..2210546 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
FPJ71_RS10205 2210533..2211027 + 495 WP_003899099.1 hypothetical protein -
FPJ71_RS10210 2211187..2211594 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
FPJ71_RS10215 2211598..2211870 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FPJ71_RS10220 2211903..2213123 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
FPJ71_RS10225 2214022..2214819 + 798 WP_003899101.1 ABC transporter permease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-93)

Antitoxin

(2-80)


Sequences


Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T132246 WP_003409896.1 NZ_CP041837:c2210298-2210002 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T132246 NZ_CP041837:c2210298-2210002 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT132246 WP_003409899.1 NZ_CP041837:c2210546-2210295 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT132246 NZ_CP041837:c2210546-2210295 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G0TLU9


Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BUZ2

References