Detailed information of TA system TA132237

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 1394230..1394789
• Replicon: chromosome
• Accession: NZ_CP041837
• Organism: Mycobacterium tuberculosis strain 2-0029P6C4

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FPJ71_RS06550
• Protein ID: WP_031712129.1
• Coordinates: 1394230..1394523 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G0THS2
• Locus tag: FPJ71_RS06555
• Protein ID: WP_003406322.1
• Coordinates: 1394520..1394789 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPJ71_RS06525	1389823..1390083	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	-
FPJ71_RS06530	1390080..1390511	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	-
FPJ71_RS06535	1390534..1392222	-	1689	WP_003910308.1	PE family protein	-
FPJ71_RS06540	1392402..1393262	+	861	WP_003900301.1	hypothetical protein	-
FPJ71_RS06545	1393343..1394173	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
FPJ71_RS06550	1394230..1394523	-	294	WP_031712129.1	type II toxin-antitoxin system mRNA interferase RelE	Toxin
FPJ71_RS06555	1394520..1394789	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FPJ71_RS06560	1394902..1398597	-	3696	WP_003898790.1	multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit	-
FPJ71_RS06565	1398739..1399527	-	789	WP_003406325.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (9-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11030.63 Da
• Isoelectric Point: 9.6275

>T132237 WP_031712129.1 NZ_CP041837:c1394523-1394230 [Mycobacterium tuberculosis]
VSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRIDLEGLHSARRGDYRVVYAIDDGHHRVEII
HIARRSASYRMNPCRPR

Nucleotide

• Length: 294 bp

>T132237 NZ_CP041837:c1394523-1394230 [Mycobacterium tuberculosis]
GTGAGCGACGACCATCCCTACCACGTGGCGATCACCGCGACAGCGGCACGCGACCTGCAACGCTTACCCGAAAAGATCGC
CGCCGCATGTGTCGAGTTTGTTTTCGGACCGCTGCTTAACAACCCGCATAGGTTGGGCAAGCCGCTGCGCATTGACCTTG
AAGGCCTCCACTCAGCCCGCCGCGGTGATTACCGCGTCGTCTACGCCATCGACGACGGCCACCACCGAGTCGAGATCATC
CACATCGCTCGTCGCAGTGCCAGCTACCGAATGAACCCGTGCCGGCCACGTTAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9766.97 Da
• Isoelectric Point: 4.8615

>AT132237 WP_003406322.1 NZ_CP041837:c1394789-1394520 [Mycobacterium tuberculosis]
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSND
EIRNRYTAR

Nucleotide

• Length: 270 bp

>AT132237 NZ_CP041837:c1394789-1394520 [Mycobacterium tuberculosis]
ATGGCTGTTGTCCCACTGGGCGAAGTCCGCAATCGCCTCTCTGAGTACGTCGCCGAAGTTGAGCTGACACACGAGCGCAT
CACGATAACCCGGCACGGTCATCCGGCGGCGGTATTGATCTCGGCCGATGACCTGGCGTCCATCGAGGAAACGCTGGAGG
TGCTACGCACCCCTGGCGCCAGCGAGGCCATTCGTGAAGGCCTCGCCGATGTTGCCGCAGGGCGCTTCGTGAGCAACGAC
GAGATCCGCAACCGTTACACCGCGCGGTGA

Structures

Antitoxin

• AlphaFold DB: G0THS2