Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 756887..757520 Replicon chromosome
Accession NZ_CP041837
Organism Mycobacterium tuberculosis strain 2-0029P6C4

Toxin (Protein)


Gene name vapC Uniprot ID G0TQD6
Locus tag FPJ71_RS03465 Protein ID WP_003403365.1
Coordinates 756887..757270 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A655G1G4
Locus tag FPJ71_RS03470 Protein ID WP_031582830.1
Coordinates 757365..757520 (-) Length 52 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ71_RS03440 752178..752714 + 537 WP_003403341.1 50S ribosomal protein L10 -
FPJ71_RS03445 752751..753143 + 393 WP_003403353.1 50S ribosomal protein L7/L12 -
FPJ71_RS03450 753136..753831 - 696 WP_003403355.1 TetR/AcrR family transcriptional regulator -
FPJ71_RS03455 753902..755408 + 1507 Protein_682 carotenoid cleavage oxygenase -
FPJ71_RS03460 755489..756499 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
FPJ71_RS03465 756887..757270 - 384 WP_003403365.1 ribonuclease VapC6 Toxin
FPJ71_RS03470 757365..757520 - 156 WP_031582830.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
FPJ71_RS03475 757596..758312 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
FPJ71_RS03480 758588..758896 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
FPJ71_RS03485 758883..759128 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
FPJ71_RS03490 759238..759675 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin -
FPJ71_RS03495 759672..759926 - 255 WP_003911263.1 antitoxin VapB7 -
FPJ71_RS03500 760040..762403 + 2364 WP_031582834.1 arylsulfatase AtsD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-44)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13959.73 Da        Isoelectric Point: 6.0803

>T132226 WP_003403365.1 NZ_CP041837:c757270-756887 [Mycobacterium tuberculosis]
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD

Download         Length: 384 bp

>T132226 NZ_CP041837:c757270-756887 [Mycobacterium tuberculosis]
TTGGCGGCTGCAACGACAACCGGAACCCACCGAGGCCTGGAACTCCGCGCTGCTCAGCGGGCCGTCGGGTCGTGCGAACC
GCAACGAGCCGAGTTCTGCCGATCAGCGCGGAATGCGGACGAGTTCGACCAGATGAGCCGGATGTTTGGTGACGTCTACC
CCGATGTGCCAGTGCCGAAATCCGTGTGGCGGTGGATCGATTCGGCACAGCACCGCCTCGCCCGGGCGGGAGCGGTGGGT
GCCCTGTCGGTTGTCGATCTGCTGATCTGCGACACTGCGGCGGCCAGGGGCCTAGTAGTCCTCCACGACGATGCCGACTA
CGAACTCGCAGAGCGTCACCTTCCCGACATCAGAGTGCGGAGGGTCGTCAGCGCCGACGACTAG

Antitoxin


Download         Length: 52 a.a.        Molecular weight: 5860.66 Da        Isoelectric Point: 5.7734

>AT132226 WP_031582830.1 NZ_CP041837:c757520-757365 [Mycobacterium tuberculosis]
VSVTQIDLDDEALADVMRTAAVHTKKEAVNLAMRDYVERFRRIEALARSRE

Download         Length: 156 bp

>AT132226 NZ_CP041837:c757520-757365 [Mycobacterium tuberculosis]
GTGTCGGTGACCCAGATCGACCTCGACGACGAAGCGCTGGCCGATGTGATGCGCACCGCCGCCGTGCACACAAAGAAGGA
AGCCGTGAACCTCGCGATGCGCGATTACGTCGAACGGTTTCGGCGCATCGAGGCCCTGGCCCGCTCGCGCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQD6

Antitoxin

Source ID Structure
AlphaFold DB A0A655G1G4

References