Detailed information of TA system TA132207

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1-PHD
• Location: 3695631..3696295
• Replicon: chromosome
• Accession: NZ_CP041836
• Organism: Mycobacterium tuberculosis strain 2-0031P6C4

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: P96917
• Locus tag: FPJ72_RS17320
• Protein ID: WP_003403246.1
• Coordinates: 3695631..3696038 (-)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: P9WF18
• Locus tag: FPJ72_RS17325
• Protein ID: WP_003403244.1
• Coordinates: 3696035..3696295 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPJ72_RS17310	3692588..3694315	+	1728	WP_003901883.1	exodeoxyribonuclease V subunit alpha	-
FPJ72_RS17315	3694408..3695559	+	1152	WP_003403248.1	FIST C-terminal domain-containing protein	-
FPJ72_RS17320	3695631..3696038	-	408	WP_003403246.1	type II toxin-antitoxin system VapC family toxin	Toxin
FPJ72_RS17325	3696035..3696295	-	261	WP_003403244.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FPJ72_RS17330	3696427..3697167	+	741	WP_003403239.1	TVP38/TMEM64 family protein	-
FPJ72_RS17335	3697261..3697656	-	396	WP_003403236.1	type II toxin-antitoxin system toxin ribonuclease C30	-
FPJ72_RS17340	3697656..3697910	-	255	WP_003403235.1	type II toxin-antitoxin system antitoxin VapB30	-
FPJ72_RS17345	3698003..3698950	-	948	WP_003403232.1	DUF732 domain-containing protein	-
FPJ72_RS17350	3699054..3700118	-	1065	WP_003898532.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (9-125)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-57)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 14376.37 Da
• Isoelectric Point: 4.3568

>T132207 WP_003403246.1 NZ_CP041836:c3696038-3695631 [Mycobacterium tuberculosis]
VSTTPAAGVLDTSVFIATESGRQLDEALIPDRVATTVVTLAELRVGVLAAATTDIRAQRLATLESVADMETLPVDDDAAR
MWARLRIHLAESGRRVRINDLWIAAVAASRALPVITQDDDFAALDGAASVEIIRV

Nucleotide

• Length: 408 bp

>T132207 NZ_CP041836:c3696038-3695631 [Mycobacterium tuberculosis]
GTGAGCACGACGCCGGCCGCCGGAGTGCTCGACACGTCGGTGTTCATCGCGACCGAAAGCGGCCGGCAACTCGACGAGGC
GCTGATCCCCGACCGGGTCGCCACCACCGTCGTCACCCTCGCCGAACTGCGCGTCGGCGTGCTGGCCGCGGCGACGACCG
ACATCCGGGCTCAACGCCTGGCGACCCTGGAATCCGTTGCCGATATGGAAACGTTGCCCGTCGACGACGATGCCGCCCGA
ATGTGGGCCCGATTGCGGATCCATCTTGCCGAGTCCGGTCGCCGGGTGCGGATCAACGACCTGTGGATCGCGGCCGTCGC
GGCATCGCGAGCGCTGCCGGTCATCACCCAGGACGACGACTTCGCCGCCCTCGACGGTGCGGCCAGTGTGGAGATCATTC
GGGTCTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9492.84 Da
• Isoelectric Point: 11.9108

>AT132207 WP_003403244.1 NZ_CP041836:c3696295-3696035 [Mycobacterium tuberculosis]
MSEVASRELRNDTAGVLRRVRAGEDVTITVSGRPVAVLTPVRPRRRRWLSKTEFLSRLRGAQADPGLRNDLAVLAGDTTE
DLGPIR

Nucleotide

• Length: 261 bp

>AT132207 NZ_CP041836:c3696295-3696035 [Mycobacterium tuberculosis]
ATGTCTGAGGTGGCCTCGCGTGAGCTGCGTAACGATACGGCCGGCGTGCTGCGCCGCGTGCGGGCAGGGGAGGACGTCAC
CATCACCGTCAGCGGCCGTCCGGTCGCGGTGCTTACCCCGGTTCGTCCGCGGCGCCGGCGTTGGCTGAGCAAAACGGAGT
TCCTGTCGCGGTTGCGCGGCGCTCAAGCCGATCCCGGGCTCCGTAACGACCTCGCGGTCCTTGCCGGCGACACGACCGAG
GATCTCGGGCCGATCCGGTGA

Structures

Toxin

• PDB: 3DBO

Antitoxin

• AlphaFold DB: A0A7U4BSE4