132197

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2951577..2952264 Replicon chromosome
Accession NZ_CP041836
Organism Mycobacterium tuberculosis strain 2-0031P6C4

Toxin (Protein)


Gene name vapC Uniprot ID P65044
Locus tag FPJ72_RS13835 Protein ID WP_003414624.1
Coordinates 2951821..2952264 (+) Length 148 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TFH0
Locus tag FPJ72_RS13830 Protein ID WP_003414620.1
Coordinates 2951577..2951834 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ72_RS13810 2946897..2947751 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
FPJ72_RS13815 2947807..2948970 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
FPJ72_RS13820 2948987..2950201 - 1215 WP_003414610.1 zinc metalloprotease Rip -
FPJ72_RS13825 2950209..2951450 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -
FPJ72_RS13830 2951577..2951834 + 258 WP_003414620.1 ribbon-helix-helix domain-containing protein Antitoxin
FPJ72_RS13835 2951821..2952264 + 444 WP_003414624.1 type II toxin-antitoxin system VapC family toxin Toxin
FPJ72_RS13840 2952344..2953006 + 663 WP_003414630.1 cell surface glycolipoprotein Mpt83 -
FPJ72_RS13845 2953102..2953293 + 192 WP_003414632.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FPJ72_RS13850 2953625..2955373 + 1749 WP_003912869.1 cytochrome c biogenesis protein DipZ -
FPJ72_RS13855 2955469..2956050 + 582 WP_003414644.1 fasciclin domain-containing protein -
FPJ72_RS13860 2956150..2956416 + 267 WP_015456449.1 DUF2631 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 148 a.a.        Molecular weight: 16595.72 Da        Isoelectric Point: 6.4890

>T132197 WP_003414624.1 NZ_CP041836:2951821-2952264 [Mycobacterium tuberculosis]
MLCVDVNVLVYAHRADLREHADYRGLLERLANDDEPLGLPDSVLAGFIRVVTNRRVFTEPTSPQDAWQAVDALLAAPAAM
RLRPGERHWMAFRQLASDVDANGNDIADAHLAAYALENNATWLSADRGFARFRRLRWRHPLDGQTHL

Download         Length: 444 bp

>T132197 NZ_CP041836:2951821-2952264 [Mycobacterium tuberculosis]
ATGCTGTGCGTTGATGTCAACGTGCTCGTTTACGCGCATCGGGCAGACCTACGGGAGCACGCGGACTATCGGGGTTTGCT
TGAGCGGCTGGCCAACGATGACGAGCCGCTGGGTCTACCAGATAGCGTGCTCGCCGGCTTCATCCGGGTGGTTACCAACC
GCCGCGTCTTCACCGAGCCGACGAGCCCACAGGACGCATGGCAGGCAGTCGACGCCCTACTCGCGGCACCCGCAGCCATG
CGACTTCGGCCTGGCGAGCGCCACTGGATGGCCTTTCGGCAGTTAGCGTCCGATGTTGATGCGAACGGCAACGACATTGC
GGACGCGCACCTGGCCGCCTACGCGCTAGAGAACAACGCAACCTGGTTGAGCGCCGACCGCGGCTTTGCCCGTTTCCGTC
GACTGCGCTGGCGTCATCCGTTGGACGGTCAGACCCATCTATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9013.22 Da        Isoelectric Point: 10.8344

>AT132197 WP_003414620.1 NZ_CP041836:2951577-2951834 [Mycobacterium tuberculosis]
VRTTIRIDDELYREVKAKAARSGRTVAAVLEDAVRRGLNPPKPQAAGRYRVQPSGKGGLRPGVDLSSNAALAEAMNDGVS
VDAVR

Download         Length: 258 bp

>AT132197 NZ_CP041836:2951577-2951834 [Mycobacterium tuberculosis]
GTGCGCACGACGATCCGTATCGATGACGAGCTGTACCGCGAGGTGAAAGCAAAGGCCGCTCGTTCCGGGCGTACCGTGGC
CGCGGTTCTTGAAGATGCGGTGCGGCGTGGTCTCAACCCGCCTAAGCCGCAGGCCGCCGGCCGTTATCGAGTCCAGCCGT
CGGGTAAGGGCGGCCTGCGGCCCGGTGTCGATCTATCGTCCAACGCCGCACTTGCCGAAGCGATGAACGACGGCGTGTCG
GTCGATGCTGTGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VWO

Antitoxin

Source ID Structure
AlphaFold DB G0TFH0

References