Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3696738..3697412 Replicon chromosome
Accession NZ_CP041835
Organism Mycobacterium tuberculosis strain 2-0034P6C4

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag FPJ73_RS17365 Protein ID WP_003417282.1
Coordinates 3696738..3697166 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag FPJ73_RS17370 Protein ID WP_003417286.1
Coordinates 3697170..3697412 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ73_RS17340 3692560..3692961 - 402 WP_003417264.1 cytidine deaminase -
FPJ73_RS17345 3693102..3693536 + 435 WP_003900017.1 succinate dehydrogenase, cytochrome b556 subunit -
FPJ73_RS17350 3693533..3693967 + 435 WP_003902441.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
FPJ73_RS17355 3694096..3695868 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
FPJ73_RS17360 3695868..3696659 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
FPJ73_RS17365 3696738..3697166 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
FPJ73_RS17370 3697170..3697412 - 243 WP_003417286.1 ribbon-helix-helix domain-containing protein Antitoxin
FPJ73_RS17375 3697534..3698148 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
FPJ73_RS17380 3698145..3698810 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
FPJ73_RS17385 3698811..3699344 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
FPJ73_RS17390 3699341..3699715 - 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -
FPJ73_RS17395 3699812..3700876 - 1065 WP_003913037.1 GTP 3',8-cyclase MoaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T132149 WP_003417282.1 NZ_CP041835:c3697166-3696738 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T132149 NZ_CP041835:c3697166-3696738 [Mycobacterium tuberculosis]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT132149 WP_003417286.1 NZ_CP041835:c3697412-3697170 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT132149 NZ_CP041835:c3697412-3697170 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References