Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2368708..2369403 Replicon chromosome
Accession NZ_CP041834
Organism Mycobacterium tuberculosis strain 2-0043-unknownP6C4

Toxin (Protein)


Gene name vapC Uniprot ID O53501
Locus tag FPJ74_RS10940 Protein ID WP_003410811.1
Coordinates 2368708..2369142 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag FPJ74_RS10945 Protein ID WP_003410814.1
Coordinates 2369149..2369403 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ74_RS10925 2364897..2366435 + 1539 WP_023637436.1 HNH endonuclease -
FPJ74_RS10930 2366634..2368304 + 1671 Protein_2161 ATP-dependent helicase -
FPJ74_RS10935 2368307..2368729 + 423 Protein_2162 SWIM zinc finger family protein -
FPJ74_RS10940 2368708..2369142 - 435 WP_003410811.1 type II toxin-antitoxin system VapC family toxin Toxin
FPJ74_RS10945 2369149..2369403 - 255 WP_003410814.1 antitoxin Antitoxin
FPJ74_RS10950 2369419..2369676 - 258 WP_003410816.1 hypothetical protein -
FPJ74_RS10955 2370623..2370919 + 297 WP_003410820.1 PE family protein -
FPJ74_RS10960 2370975..2371706 + 732 WP_003900467.1 PPE family protein -
FPJ74_RS10965 2372246..2372992 - 747 WP_003899174.1 proteasome subunit alpha -
FPJ74_RS10970 2372989..2373864 - 876 WP_003411023.1 proteasome subunit beta -
FPJ74_RS10975 2373861..2374055 - 195 WP_003411026.1 ubiquitin-like protein Pup -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15662.08 Da        Isoelectric Point: 7.4681

>T132072 WP_003410811.1 NZ_CP041834:c2369142-2368708 [Mycobacterium tuberculosis]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

>T132072 NZ_CP041834:c2369142-2368708 [Mycobacterium tuberculosis]
ATGAAGATCGTCGACGCGAACGTCTTGCTCTACGCCGTGAACACCACAAGTGAGCACCACAAGCCGTCGCTGCGCTGGCT
TGACGGTGCGCTGTCGGGCGCCGACCGCGTCGGGTTCGCCTGGGTGCCGTTGTTGGCGTTCGTGCGATTGGCGACCAAGG
TGGGGTTGTTCCCCCGTCCGCTTCCGCGGGAGGCGGCCATCACCCAGGTCGCGGATTGGCTAGCCGCACCCAGCGCCGTC
TTGGTGAATCCGACCGTCCGGCACGCCGATATCCTGGCGAGAATGCTGACGTACGTGGGAACCGGTGCCAACCTGGTCAA
CGACGCGCATCTGGCCGCGCTTGCCGTCGAGCATCGCGCCAGCATCGTGTCCTACGACAGTGACTTCGGCCGATTCGAAG
GGGTGCGCTGGGATCAGCCGCCCGCGCTGTTGTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT132072 WP_003410814.1 NZ_CP041834:c2369403-2369149 [Mycobacterium tuberculosis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp

>AT132072 NZ_CP041834:c2369403-2369149 [Mycobacterium tuberculosis]
ATGCGGACGACTGTCACATTGGATGACGACGTCGAGCAGTTGGTAAGGCGCCGGATGGCCGAGCGGCAAGTGTCCTTCAA
GAAGGCCCTCAACGACGCGATTCGCGACGGCGCCTCCGGGCGACCTGCGCCGAGTCACTTCAGCACCCGCACGGCAGACT
TGGGCGTCCCTGCGGTCAACCTCGACCGGGCCTTGCAGCTTGCGGCCGACCTCGAGGACGAAGAGCTTGTGCGCCGTCAA
CGCCGCGGGTCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB09

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References