132048

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 760316..761004 Replicon chromosome
Accession NZ_CP041834
Organism Mycobacterium tuberculosis strain 2-0043-unknownP6C4

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB2
Locus tag FPJ74_RS03490 Protein ID WP_003403386.1
Coordinates 760316..760753 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O06777
Locus tag FPJ74_RS03495 Protein ID WP_003911263.1
Coordinates 760750..761004 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ74_RS03460 756567..757577 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
FPJ74_RS03465 757965..758348 - 384 WP_003403365.1 ribonuclease VapC6 -
FPJ74_RS03470 758443..758598 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin -
FPJ74_RS03475 758674..759390 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
FPJ74_RS03480 759666..759974 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
FPJ74_RS03485 759961..760206 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
FPJ74_RS03490 760316..760753 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin Toxin
FPJ74_RS03495 760750..761004 - 255 WP_003911263.1 antitoxin VapB7 Antitoxin
FPJ74_RS03500 761118..763481 + 2364 WP_193055468.1 arylsulfatase AtsD -
FPJ74_RS03505 763544..763870 + 327 WP_003403401.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FPJ74_RS03510 763782..764120 + 339 WP_003403405.1 PIN domain-containing protein -
FPJ74_RS03515 764117..764290 + 174 WP_003898549.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15245.39 Da        Isoelectric Point: 5.1865

>T132048 WP_003403386.1 NZ_CP041834:c760753-760316 [Mycobacterium tuberculosis]
MIVLDTTVLVYAKGAEHPLRDPCRDLVAAIADERIAATTTAEVIQEFVHVRARRRDRSDAAALGRVTMPNCSRRYSPSIE
ATSKRGLTLFETTPGLEACDAVLAAVAASAGATALVSADPAFADLSDVVHVIPDAAGMVSLLGDR

Download         Length: 438 bp

>T132048 NZ_CP041834:c760753-760316 [Mycobacterium tuberculosis]
ATGATAGTGCTCGACACCACCGTCCTCGTCTATGCCAAAGGCGCCGAGCATCCACTCCGCGATCCCTGCCGCGATCTCGT
CGCGGCAATCGCCGACGAACGCATCGCTGCGACCACCACCGCCGAGGTGATCCAGGAGTTCGTCCACGTACGCGCCCGCC
GGCGCGACCGCAGCGACGCCGCCGCGCTGGGCCGTGTGACTATGCCGAACTGCTCTCGCCGCTACTCACCATCAATCGAG
GCCACCTCGAAGCGCGGCCTGACGCTGTTCGAGACAACGCCAGGGCTTGAAGCCTGCGACGCGGTGCTCGCGGCGGTTGC
CGCAAGCGCCGGCGCGACCGCTCTTGTCTCGGCTGACCCGGCGTTCGCCGATCTGTCGGATGTCGTGCACGTCATTCCCG
ACGCGGCCGGGATGGTCAGCCTGCTCGGCGACCGCTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9450.99 Da        Isoelectric Point: 11.7073

>AT132048 WP_003911263.1 NZ_CP041834:c761004-760750 [Mycobacterium tuberculosis]
MSMRLAHRLQILLDDECHRRITAVARERGVPVATVVREAIDRGLVSPAGRRKSAGRRLLDAADMSVPEPRELKQELEALR
ARRG

Download         Length: 255 bp

>AT132048 NZ_CP041834:c761004-760750 [Mycobacterium tuberculosis]
ATGAGCATGCGTCTGGCGCATCGGCTCCAGATCCTGCTCGACGACGAGTGCCACCGCCGCATCACCGCGGTGGCGCGCGA
GCGAGGCGTCCCGGTCGCAACCGTCGTGCGTGAGGCCATTGATCGAGGCCTCGTCAGCCCCGCCGGTCGCCGCAAGTCCG
CGGGCAGGCGCCTGCTCGACGCCGCCGACATGTCCGTTCCCGAGCCGCGGGAGCTGAAGCAGGAACTCGAGGCCCTCCGG
GCGCGCCGCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSW5

Antitoxin

Source ID Structure
AlphaFold DB A0A806JQG1

References