Detailed information of TA system TA131995

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 1394228..1394787
• Replicon: chromosome
• Accession: NZ_CP041833
• Organism: Mycobacterium tuberculosis strain 2-0046P6C4

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FPJ75_RS06545
• Protein ID: WP_031712129.1
• Coordinates: 1394228..1394521 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G0THS2
• Locus tag: FPJ75_RS06550
• Protein ID: WP_003406322.1
• Coordinates: 1394518..1394787 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPJ75_RS06520	1389821..1390081	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	-
FPJ75_RS06525	1390078..1390509	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	-
FPJ75_RS06530	1390532..1392220	-	1689	WP_003910308.1	PE family protein	-
FPJ75_RS06535	1392400..1393260	+	861	WP_003900301.1	hypothetical protein	-
FPJ75_RS06540	1393341..1394171	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
FPJ75_RS06545	1394228..1394521	-	294	WP_031712129.1	type II toxin-antitoxin system mRNA interferase RelE	Toxin
FPJ75_RS06550	1394518..1394787	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FPJ75_RS06555	1394900..1398595	-	3696	WP_003898790.1	multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit	-
FPJ75_RS06560	1398737..1399525	-	789	WP_003406325.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (9-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11030.63 Da
• Isoelectric Point: 9.6275

>T131995 WP_031712129.1 NZ_CP041833:c1394521-1394228 [Mycobacterium tuberculosis]
VSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRIDLEGLHSARRGDYRVVYAIDDGHHRVEII
HIARRSASYRMNPCRPR

Nucleotide

• Length: 294 bp

>T131995 NZ_CP041833:c1394521-1394228 [Mycobacterium tuberculosis]
GTGAGCGACGACCATCCCTACCACGTGGCGATCACCGCGACAGCGGCACGCGACCTGCAACGCTTACCCGAAAAGATCGC
CGCCGCATGTGTCGAGTTTGTTTTCGGACCGCTGCTTAACAACCCGCATAGGTTGGGCAAGCCGCTGCGCATTGACCTTG
AAGGCCTCCACTCAGCCCGCCGCGGTGATTACCGCGTCGTCTACGCCATCGACGACGGCCACCACCGAGTCGAGATCATC
CACATCGCTCGTCGCAGTGCCAGCTACCGAATGAACCCGTGCCGGCCACGTTAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9766.97 Da
• Isoelectric Point: 4.8615

>AT131995 WP_003406322.1 NZ_CP041833:c1394787-1394518 [Mycobacterium tuberculosis]
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSND
EIRNRYTAR

Nucleotide

• Length: 270 bp

>AT131995 NZ_CP041833:c1394787-1394518 [Mycobacterium tuberculosis]
ATGGCTGTTGTCCCACTGGGCGAAGTCCGCAATCGCCTCTCTGAGTACGTCGCCGAAGTTGAGCTGACACACGAGCGCAT
CACGATAACCCGGCACGGTCATCCGGCGGCGGTATTGATCTCGGCCGATGACCTGGCGTCCATCGAGGAAACGCTGGAGG
TGCTACGCACCCCTGGCGCCAGCGAGGCCATTCGTGAAGGCCTCGCCGATGTTGCCGCAGGGCGCTTCGTGAGCAACGAC
GAGATCCGCAACCGTTACACCGCGCGGTGA

Structures

Antitoxin

• AlphaFold DB: G0THS2