Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 756888..757521 Replicon chromosome
Accession NZ_CP041833
Organism Mycobacterium tuberculosis strain 2-0046P6C4

Toxin (Protein)


Gene name vapC Uniprot ID G0TQD6
Locus tag FPJ75_RS03460 Protein ID WP_003403365.1
Coordinates 756888..757271 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A655G1G4
Locus tag FPJ75_RS03465 Protein ID WP_031582830.1
Coordinates 757366..757521 (-) Length 52 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ75_RS03435 752179..752715 + 537 WP_003403341.1 50S ribosomal protein L10 -
FPJ75_RS03440 752752..753144 + 393 WP_003403353.1 50S ribosomal protein L7/L12 -
FPJ75_RS03445 753137..753832 - 696 WP_003403355.1 TetR/AcrR family transcriptional regulator -
FPJ75_RS03450 753903..755409 + 1507 Protein_681 carotenoid cleavage oxygenase -
FPJ75_RS03455 755490..756500 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
FPJ75_RS03460 756888..757271 - 384 WP_003403365.1 ribonuclease VapC6 Toxin
FPJ75_RS03465 757366..757521 - 156 WP_031582830.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
FPJ75_RS03470 757597..758313 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
FPJ75_RS03475 758589..758897 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
FPJ75_RS03480 758884..759129 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
FPJ75_RS03485 759239..759676 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin -
FPJ75_RS03490 759673..759927 - 255 WP_003911263.1 antitoxin VapB7 -
FPJ75_RS03495 760041..762404 + 2364 WP_031582834.1 arylsulfatase AtsD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-44)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13959.73 Da        Isoelectric Point: 6.0803

>T131984 WP_003403365.1 NZ_CP041833:c757271-756888 [Mycobacterium tuberculosis]
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD

Download         Length: 384 bp

>T131984 NZ_CP041833:c757271-756888 [Mycobacterium tuberculosis]
TTGGCGGCTGCAACGACAACCGGAACCCACCGAGGCCTGGAACTCCGCGCTGCTCAGCGGGCCGTCGGGTCGTGCGAACC
GCAACGAGCCGAGTTCTGCCGATCAGCGCGGAATGCGGACGAGTTCGACCAGATGAGCCGGATGTTTGGTGACGTCTACC
CCGATGTGCCAGTGCCGAAATCCGTGTGGCGGTGGATCGATTCGGCACAGCACCGCCTCGCCCGGGCGGGAGCGGTGGGT
GCCCTGTCGGTTGTCGATCTGCTGATCTGCGACACTGCGGCGGCCAGGGGCCTAGTAGTCCTCCACGACGATGCCGACTA
CGAACTCGCAGAGCGTCACCTTCCCGACATCAGAGTGCGGAGGGTCGTCAGCGCCGACGACTAG

Antitoxin


Download         Length: 52 a.a.        Molecular weight: 5860.66 Da        Isoelectric Point: 5.7734

>AT131984 WP_031582830.1 NZ_CP041833:c757521-757366 [Mycobacterium tuberculosis]
VSVTQIDLDDEALADVMRTAAVHTKKEAVNLAMRDYVERFRRIEALARSRE

Download         Length: 156 bp

>AT131984 NZ_CP041833:c757521-757366 [Mycobacterium tuberculosis]
GTGTCGGTGACCCAGATCGACCTCGACGACGAAGCGCTGGCCGATGTGATGCGCACCGCCGCCGTGCACACAAAGAAGGA
AGCCGTGAACCTCGCGATGCGCGATTACGTCGAACGGTTTCGGCGCATCGAGGCCCTGGCCCGCTCGCGCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQD6

Antitoxin

Source ID Structure
AlphaFold DB A0A655G1G4

References