Detailed information of TA system TA131964

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 3160484..3161032
• Replicon: chromosome
• Accession: NZ_CP041832
• Organism: Mycobacterium tuberculosis strain 2-0052P6C4

Toxin (Protein)

• Gene name: relE
• Uniprot ID: G0TFG5
• Locus tag: FPJ76_RS14940
• Protein ID: WP_003414602.1
• Coordinates: 3160769..3161032 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FPJ76_RS14935
• Protein ID: WP_031682117.1
• Coordinates: 3160484..3160765 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPJ76_RS14910	3156107..3156964	-	858	WP_003899513.1	type I methionyl aminopeptidase	-
FPJ76_RS14915	3157006..3157590	-	585	WP_003414585.1	DUF1707 domain-containing protein	-
FPJ76_RS14920	3157694..3157942	+	249	WP_003913411.1	antitoxin VapB23	-
FPJ76_RS14925	3157939..3158319	+	381	WP_003414592.1	type II toxin-antitoxin system VapC family toxin	-
FPJ76_RS14930	3158401..3160212	-	1812	WP_003414596.1	penicillin-binding protein	-
FPJ76_RS14935	3160484..3160765	+	282	WP_031682117.1	type II toxin-antitoxin system antitoxin RelF	Antitoxin
FPJ76_RS14940	3160769..3161032	+	264	WP_003414602.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FPJ76_RS14945	3161405..3162259	-	855	WP_003899516.1	GNAT family N-acetyltransferase	-
FPJ76_RS14950	3162315..3163478	-	1164	WP_003899517.1	flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase	-
FPJ76_RS14955	3163495..3164709	-	1215	WP_003414610.1	zinc metalloprotease Rip	-
FPJ76_RS14960	3164717..3165958	-	1242	WP_003414613.1	1-deoxy-D-xylulose-5-phosphate reductoisomerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10204.82 Da
• Isoelectric Point: 11.5078

>T131964 WP_003414602.1 NZ_CP041832:3160769-3161032 [Mycobacterium tuberculosis]
VPYTVRFTTTARRDLHKLPPRILAAVVEFAFGDLSREPLRVGKPLRRELAGTFSARRGTYRLLYRIDDEHTTVVILRVDH
RADIYRR

Nucleotide

• Length: 264 bp

>T131964 NZ_CP041832:3160769-3161032 [Mycobacterium tuberculosis]
GTGCCTTACACCGTGCGGTTCACCACAACCGCGCGTCGAGACCTCCACAAGCTGCCACCGCGAATCCTCGCGGCAGTGGT
CGAATTCGCGTTCGGCGATCTGTCGCGCGAGCCCCTGCGGGTGGGCAAGCCCCTTCGGCGCGAGTTGGCCGGCACGTTCA
GCGCGCGTCGCGGAACGTACCGCCTGCTGTACCGGATTGACGACGAGCACACAACGGTAGTGATCCTGCGCGTCGATCAC
CGCGCGGACATCTACCGCCGATAG

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10213.42 Da
• Isoelectric Point: 4.3440

>AT131964 WP_031682117.1 NZ_CP041832:3160484-3160765 [Mycobacterium tuberculosis]
MRILPISTIKGKLNEFVDAVSSTQDQITITKNGAPAAVLVGTDEWESLQETLYWLAQPGIRESIAEADADIASGRTYGED
EIRAEFGVPRRPH

Nucleotide

• Length: 282 bp

>AT131964 NZ_CP041832:3160484-3160765 [Mycobacterium tuberculosis]
ATGCGGATACTGCCGATTTCGACGATCAAGGGCAAGCTCAATGAGTTCGTCGACGCGGTCTCGTCGACACAGGACCAGAT
CACCATCACCAAGAACGGTGCACCCGCAGCCGTTCTGGTCGGCACCGACGAGTGGGAATCGTTGCAGGAGACGCTGTACT
GGCTGGCGCAACCCGGAATCAGGGAGTCGATCGCTGAAGCCGACGCCGACATTGCCTCCGGCCGCACCTACGGCGAAGAC
GAGATCCGCGCCGAATTCGGCGTCCCGCGACGCCCCCACTGA

Structures

Toxin

• PDB: 3G5O