Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 705570..706195 Replicon chromosome
Accession NZ_CP041832
Organism Mycobacterium tuberculosis strain 2-0052P6C4

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag FPJ76_RS03200 Protein ID WP_003403218.1
Coordinates 705794..706195 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag FPJ76_RS03195 Protein ID WP_003403213.1
Coordinates 705570..705797 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ76_RS03170 700749..700970 - 222 WP_003898525.1 DUF4926 domain-containing protein -
FPJ76_RS03175 701112..701717 + 606 WP_031682044.1 hypothetical protein -
FPJ76_RS03180 701736..704303 - 2568 WP_003901879.1 SEC-C domain-containing protein -
FPJ76_RS03185 704387..705136 + 750 WP_031682045.1 hypothetical protein -
FPJ76_RS03190 705133..705375 + 243 WP_003403210.1 hypothetical protein -
FPJ76_RS03195 705570..705797 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
FPJ76_RS03200 705794..706195 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
FPJ76_RS03205 706324..707019 + 696 WP_003900189.1 galactose-1-phosphate uridylyltransferase -
FPJ76_RS03210 707016..707507 + 492 WP_003905354.1 galactose-1-phosphate uridylyltransferase -
FPJ76_RS03215 707504..708595 + 1092 WP_003900977.1 galactokinase -
FPJ76_RS03220 708990..710054 + 1065 WP_003898532.1 hypothetical protein -
FPJ76_RS03225 710158..711105 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T131921 WP_003403218.1 NZ_CP041832:705794-706195 [Mycobacterium tuberculosis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T131921 NZ_CP041832:705794-706195 [Mycobacterium tuberculosis]
GTGACGGTGCTGCTCGACGCCAACGTGCTGATCGCATTGGTGGTCGCCGAGCATGTGCATCATGATGCCGCAGCGGACTG
GCTCATGGCGTCCGACACCGGATTTGCGACCTGCCCGATGACACAAGGAAGCCTGGTTCGATTCCTGGTGCGCTCGGGAC
AGTCCGCGGCGGCGGCTCGGGATGTCGTCAGTGCGGTCCAGTGCACGAGCCGCCACGAATTCTGGCCCGATGCACTCTCT
TTCGCCGGTGTCGAGGTCGCTGGTGTGGTTGGGCACCGGCAGGTGACCGATGCCTACCTTGCCCAGCTCGCGCGAAGCCA
CGACGGGCAGTTGGCGACGCTCGACAGCGGCTTAGCACACCTGCACGGCGACGTCGCGGTACTCATTCCAACGACCACCT
GA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT131921 WP_003403213.1 NZ_CP041832:705570-705797 [Mycobacterium tuberculosis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT131921 NZ_CP041832:705570-705797 [Mycobacterium tuberculosis]
GTGCGCACTACCATCGACCTGCCGCAAGACCTGCACAAGCAGGCACTGGCGATTGCCCGGGATACGCACCGCACGTTGAG
TGAAACGGTCGCCGACCTCATGCGACGAGGCCTGGCCGCCAACCGCCCTACCGCGTTGTCCTCAGACCCCAGAACGGGAT
TGCCTTTGGTGAGCGTCGGGACCGTCGTGACCTCCGAGGACGTGCGTTCATTAGAGGACGAGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References