Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 698032..698675 Replicon chromosome
Accession NZ_CP041832
Organism Mycobacterium tuberculosis strain 2-0052P6C4

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag FPJ76_RS03150 Protein ID WP_003403187.1
Coordinates 698274..698675 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag FPJ76_RS03145 Protein ID WP_003403184.1
Coordinates 698032..698277 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ76_RS03110 693312..693842 - 531 WP_003917320.1 two component system sensor kinase HK2 -
FPJ76_RS03115 693826..694587 - 762 WP_003403148.1 two-component system response regulator TcrA -
FPJ76_RS03120 694644..694955 + 312 WP_003403164.1 hypothetical protein -
FPJ76_RS03125 695027..695977 + 951 WP_003900184.1 DUF1259 domain-containing protein -
FPJ76_RS03130 696218..696802 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
FPJ76_RS03135 696804..697514 + 711 Protein_621 transposase -
FPJ76_RS03140 697517..697987 + 471 WP_003898523.1 hypothetical protein -
FPJ76_RS03145 698032..698277 + 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
FPJ76_RS03150 698274..698675 + 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
FPJ76_RS03155 699063..699230 - 168 WP_077385191.1 DUF3800 domain-containing protein -
FPJ76_RS03160 699263..699460 - 198 WP_003403191.1 hypothetical protein -
FPJ76_RS03165 699540..700697 - 1158 WP_003898524.1 hypothetical protein -
FPJ76_RS03170 700749..700970 - 222 WP_003898525.1 DUF4926 domain-containing protein -
FPJ76_RS03175 701112..701717 + 606 WP_031682044.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T131920 WP_003403187.1 NZ_CP041832:698274-698675 [Mycobacterium tuberculosis]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

>T131920 NZ_CP041832:698274-698675 [Mycobacterium tuberculosis]
GTGATCGTCGACACGTCGGCGATCATCGCGATTCTGCGCGACGAGGACGACGCCGCGGCCTACGCCGACGCGCTCGCCAA
CGCCGATGTCCGCAGACTGTCTGCGGCCAGCTACCTGGAATGCGGGATAGTCCTTGACTCCCAGCGTGATCCGGTCATCA
GCAGAGCACTGGATGAACTTATCGAAGAAGCCGAGTTCGTCGTCGAGCCGGTAACCGAGCGCCAGGCCCGCCTGGCCCGA
GCGGCCTACGCGGATTTCGGCAGAGGCAGCGGCCACCCCGCGGGCTTGAATTTCGGCGACTGCCTGTCCTATGCACTGGC
GATCGATCGACGTGAGCCGCTGCTGTGGAAGGGCAACGACTTTGGGCACACCGGCGTCCAAAGGGCACTGGATCGGCGGT
GA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT131920 WP_003403184.1 NZ_CP041832:698032-698277 [Mycobacterium tuberculosis]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp

>AT131920 NZ_CP041832:698032-698277 [Mycobacterium tuberculosis]
ATGGCGTTGAACATCAAAGATCCGTCGGTTCACCAGGCGGTCAAGCAGATCGCGAAAATCACCGGCGAATCTCAGGCTCG
GGCGGTGGCGACCGCGGTGAACGAGCGTCTGGCCAGACTGCGCAGCGACGATCTCGCCGCCCGGCTCTTGGCTATCGGCC
ACAAGACCGCGAGCAGGATGAGCCCGGAAGCAAAGCGCCTCGACCACGATGCTCTGCTGTATGACGAGCGAGGGCTGCCG
GCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References