131896

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2740152..2740765 Replicon chromosome
Accession NZ_CP041831
Organism Mycobacterium tuberculosis strain 2-0059P6C4

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag FPJ77_RS12745 Protein ID WP_003408465.1
Coordinates 2740376..2740765 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag FPJ77_RS12740 Protein ID WP_003408469.1
Coordinates 2740152..2740379 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ77_RS12720 2736044..2736754 + 711 WP_003408486.1 winged helix-turn-helix transcriptional regulator -
FPJ77_RS12725 2736744..2737163 + 420 WP_003408483.1 hypothetical protein -
FPJ77_RS12730 2737206..2738453 - 1248 WP_003408476.1 serine hydrolase -
FPJ77_RS12735 2738450..2739934 - 1485 WP_003408473.1 carboxylase -
FPJ77_RS12740 2740152..2740379 + 228 WP_003408469.1 antitoxin Antitoxin
FPJ77_RS12745 2740376..2740765 + 390 WP_003408465.1 PIN domain-containing protein Toxin
FPJ77_RS12755 2741375..2742154 - 780 WP_003408460.1 IclR family transcriptional regulator -
FPJ77_RS12760 2742168..2742986 - 819 WP_003408456.1 3-keto-5-aminohexanoate cleavage protein -
FPJ77_RS12765 2743039..2743389 - 351 WP_003898986.1 cupin domain-containing protein -
FPJ77_RS12770 2743389..2744219 - 831 WP_003408448.1 cyclase family protein -
FPJ77_RS12775 2744222..2745136 - 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T131896 WP_003408465.1 NZ_CP041831:2740376-2740765 [Mycobacterium tuberculosis]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

>T131896 NZ_CP041831:2740376-2740765 [Mycobacterium tuberculosis]
GTGATCGTGTTGGACGCCTCGGCGGCCGTCGAGCTCATGCTCACGACGCCGGCGGGTGCGGCGGTCGCCCGGCGCTTGCG
GGGCGAAACCGTGCACGCCCCTGCACATTTCGATGTCGAGGTGATCGGGGCGATACGTCAAGCGGTCGTGCGTCAGCTGA
TCAGCGATCATGAAGGACTCGTCGTGGTTGTCAACTTCCTTAGCCTGCCCGTTCGGCGTTGGCCGTTAAAGCCATTCACC
CAGCGTGCCTACCAACTTCGGTCCACTCATACCGTGGCCGATGGAGCCTACGTCGCCCTCGCCGAGGGCCTCGGCGTACC
GCTTATCACTTGCGACGGGCGACTTGCCCAATCCCATGGCCATAATGCGGAGATCGAGCTTGTCGCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT131896 WP_003408469.1 NZ_CP041831:2740152-2740379 [Mycobacterium tuberculosis]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp

>AT131896 NZ_CP041831:2740152-2740379 [Mycobacterium tuberculosis]
ATGTCCGCCATGGTTCAGATCCGCAACGTTCCCGACGAGCTTCTCCACGAGCTGAAGGCCCGCGCAGCGGCGCAACGGAT
GAGCCTGAGCGATTTCCTCCTAGCACGGCTTGCCGAGATCGCGGAAGAACCGGCCCTCGACGACGTTCTCGACCGTCTAG
CGGCACTGCCGCGCCGGGATCTCGGCGCGAGCGCAGCCGAGCTTGTTGACGAGGCTCGATCTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAN9

References