Detailed information of TA system TA131890

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mbcAT/RES-Xre
• Location: 2447260..2448158
• Replicon: chromosome
• Accession: NZ_CP041831
• Organism: Mycobacterium tuberculosis strain 2-0059P6C4

Toxin (Protein)

• Gene name: mbcT
• Uniprot ID: P64908
• Locus tag: FPJ77_RS11355
• Protein ID: WP_003410001.1
• Coordinates: 2447598..2448158 (+)
• Length: 187 a.a.

Antitoxin (Protein)

• Gene name: mbcA
• Uniprot ID: -
• Locus tag: FPJ77_RS11350
• Protein ID: WP_031718015.1
• Coordinates: 2447260..2447601 (+)
• Length: 114 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPJ77_RS11315	2442913..2443269	+	357	WP_003410018.1	Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR	-
FPJ77_RS11320	2443322..2443594	+	273	WP_003410017.1	DUF1490 family protein	-
FPJ77_RS11325	2443591..2445906	+	2316	WP_031582628.1	cation transporter ATPase CptG	-
FPJ77_RS11330	2446006..2446254	+	249	WP_003410014.1	ribbon-helix-helix protein, CopG family	-
FPJ77_RS11335	2446248..2446592	+	345	WP_003410010.1	type II toxin-antitoxin system toxin endoribonuclease MazF6	-
FPJ77_RS11340	2446681..2447016	+	336	WP_003410009.1	dehydrogenase	-
FPJ77_RS11345	2446917..2447174	-	258	WP_003410006.1	hypothetical protein	-
FPJ77_RS11350	2447260..2447601	+	342	WP_031718015.1	DUF2384 domain-containing protein	Antitoxin
FPJ77_RS11355	2447598..2448158	+	561	WP_003410001.1	RES family NAD+ phosphorylase	Toxin
FPJ77_RS11360	2448678..2449217	-	540	WP_003900446.1	23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37)	-
FPJ77_RS11365	2449443..2449871	-	429	WP_003409992.1	cellulose-binding protein	-
FPJ77_RS11370	2450287..2450886	-	600	WP_003409989.1	L-lysine exporter	-
FPJ77_RS11375	2450995..2451906	+	912	WP_003409986.1	ArgP/LysG family DNA-binding transcriptional regulator	-
FPJ77_RS11380	2451991..2452221	-	231	WP_031714219.1	DUF167 domain-containing protein	-
FPJ77_RS11385	2452336..2452989	+	654	WP_003409976.1	cutinase Cfp21	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (25-148)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (69-110)

Sequences

Toxin

Protein

• Length: 187 a.a.
• Molecular weight: 20248.70 Da
• Isoelectric Point: 4.5091

>T131890 WP_003410001.1 NZ_CP041831:2447598-2448158 [Mycobacterium tuberculosis]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT

Nucleotide

• Length: 561 bp

>T131890 NZ_CP041831:2447598-2448158 [Mycobacterium tuberculosis]
GTGAGCGATGCCCTCGATGAAGGGCTCGTCCAGCGTATCGACGCACGCGGAACAATTGAGTGGTCGGAAACGTGCTACCG
GTATACCGGCGCGCACCGTGACGCCTTGTCCGGTGAGGGCGCGCGCAGATTCGGAGGCAGGTGGAATCCGCCGCTGCTCT
TTCCGGCGATCTATCTTGCTGATTCCGCCCAAGCCTGCATGGTTGAGGTGGAACGGGCGGCGCAAGCGGCTTCAACGACC
GCAGAGAAGATGCTCGAGGCGGCCTACCGACTACACACGATCGACGTCACGGACCTGGCCGTCCTCGATCTGACAACCCC
GCAAGCTCGGGAAGCCGTGGGGCTCGAGAACGACGACATCTATGGCGACGACTGGTCAGGGTGCCAGGCGGTCGGACATG
CGGCCTGGTTCTTGCACATGCAAGGTGTCCTCGTGCCGGCGGCGGGCGGTGTCGGCCTCGTTGTCACCGCGTATGAACAG
CGAACTCGGCCGGGCCAACTACAACTGCGACAAAGCGTCGATCTGACGCCTGCTCTTTACCAAGAACTTCGAGCCACGTA
G

Antitoxin

Protein

• Length: 114 a.a.
• Molecular weight: 12520.39 Da
• Isoelectric Point: 4.8359

>AT131890 WP_031718015.1 NZ_CP041831:2447260-2447601 [Mycobacterium tuberculosis]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEMLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Nucleotide

• Length: 342 bp

>AT131890 NZ_CP041831:2447260-2447601 [Mycobacterium tuberculosis]
ATGGGAGTAAATGTGCTCGCCTCGACCGTGTCGGGTGCGATCGAGCGCTTGGGATTGACCTACGAGGAAGTCGGTGACAT
CGTCGATGCCTCGCCGCGTTCCGTGGCGCGATGGACCGCAGGTCAGGTGGTTCCCCAACGCCTCAACAAGCAACGACTTA
TCGAGCTGGCCTATGTCGCCGACGCCCTCGCGGAAATGCTGCCGCGTGACCAGGCGAACGTGTGGATGTTTTCGCCGAAT
CGGTTACTGGAACACCGCAAGCCTGCCGACCTCGTGCGAGACGGCGAGTACCAACGCGTGTTGGCGCTCATCGACGCGAT
GGCGGAGGGAGTGTTCGTGTGA

Structures

Toxin

• PDB: 6FKG