131884

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2274478..2275007 Replicon chromosome
Accession NZ_CP041831
Organism Mycobacterium tuberculosis strain 2-0059P6C4

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag FPJ77_RS10555 Protein ID WP_003411124.1
Coordinates 2274690..2275007 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag FPJ77_RS10550 Protein ID WP_003411127.1
Coordinates 2274478..2274693 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ77_RS10525 2269886..2270176 + 291 WP_003900476.1 YggT family protein -
FPJ77_RS10530 2270384..2271645 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -
FPJ77_RS10535 2271802..2272584 + 783 WP_003411131.1 cell wall synthesis protein Wag31 -
FPJ77_RS10540 2272679..2273035 + 357 WP_003411130.1 hypothetical protein -
FPJ77_RS10545 2273165..2274223 - 1059 WP_003411129.1 hypothetical protein -
FPJ77_RS10550 2274478..2274693 + 216 WP_003411127.1 antitoxin ParD2 Antitoxin
FPJ77_RS10555 2274690..2275007 + 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FPJ77_RS10565 2275594..2276940 + 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
FPJ77_RS10570 2276988..2277518 + 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
FPJ77_RS10575 2277523..2278596 - 1074 WP_003411116.1 quinone-dependent dihydroorotate dehydrogenase -
FPJ77_RS10580 2278632..2278913 - 282 WP_003411112.1 hypothetical protein -
FPJ77_RS10585 2278910..2279986 - 1077 WP_003411110.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T131884 WP_003411124.1 NZ_CP041831:2274690-2275007 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T131884 NZ_CP041831:2274690-2275007 [Mycobacterium tuberculosis]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT131884 WP_003411127.1 NZ_CP041831:2274478-2274693 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT131884 NZ_CP041831:2274478-2274693 [Mycobacterium tuberculosis]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References