131880

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 1803183..1803814 Replicon chromosome
Accession NZ_CP041831
Organism Mycobacterium tuberculosis strain 2-0059P6C4

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ28
Locus tag FPJ77_RS08355 Protein ID WP_003413174.1
Coordinates 1803183..1803560 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P95006
Locus tag FPJ77_RS08360 Protein ID WP_003413167.1
Coordinates 1803557..1803814 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ77_RS08320 1798650..1799162 + 513 WP_003413197.1 Holliday junction resolvase RuvX -
FPJ77_RS08325 1799155..1800408 + 1254 WP_003413196.1 endolytic transglycosylase MltG -
FPJ77_RS08330 1800405..1801214 + 810 WP_003413193.1 shikimate dehydrogenase -
FPJ77_RS08335 1801226..1801645 + 420 WP_003413190.1 A24 family peptidase -
FPJ77_RS08340 1802056..1802301 + 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 -
FPJ77_RS08345 1802298..1802693 + 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 -
FPJ77_RS08350 1802793..1803167 + 375 WP_003413177.1 hypothetical protein -
FPJ77_RS08355 1803183..1803560 - 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin Toxin
FPJ77_RS08360 1803557..1803814 - 258 WP_003413167.1 ribbon-helix-helix domain-containing protein Antitoxin
FPJ77_RS08365 1803853..1804266 - 414 WP_003413164.1 PIN domain nuclease -
FPJ77_RS08370 1804359..1804637 - 279 WP_003901422.1 type II toxin-antitoxin system VapB family antitoxin -
FPJ77_RS08375 1804634..1805296 - 663 WP_003900848.1 hypothetical protein -
FPJ77_RS08380 1805293..1805952 - 660 WP_003900847.1 hypothetical protein -
FPJ77_RS08385 1805949..1806608 - 660 WP_003900846.1 LppA family lipoprotein -
FPJ77_RS08390 1806735..1807946 - 1212 WP_003900845.1 alpha/beta hydrolase family protein -
FPJ77_RS08395 1808242..1808556 - 315 WP_009937839.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13728.72 Da        Isoelectric Point: 4.4687

>T131880 WP_003413174.1 NZ_CP041831:c1803560-1803183 [Mycobacterium tuberculosis]
VKLIDTTIAVDHLRGEPAAAVLLAELINNGEEIAASELVRFELLAGVRESELAALEAFFSAVVWTLVTEDIARIGGRLAR
RYRSSHRGIDDVDYLIAATAIVVDADLLTTNVRHFPMFPDLQPPY

Download         Length: 378 bp

>T131880 NZ_CP041831:c1803560-1803183 [Mycobacterium tuberculosis]
GTGAAGCTGATCGACACCACCATCGCGGTCGACCACCTTCGCGGCGAACCCGCGGCAGCCGTGCTGCTCGCCGAACTGAT
AAACAACGGTGAGGAGATCGCGGCCAGCGAGCTGGTCCGATTCGAACTCCTCGCCGGTGTGCGGGAAAGCGAACTCGCGG
CGCTCGAGGCCTTCTTCTCGGCAGTGGTGTGGACCCTGGTGACCGAGGACATTGCCCGGATCGGCGGACGACTCGCCCGT
CGATACCGGTCCAGCCACCGCGGTATCGACGACGTGGACTACCTGATCGCTGCGACCGCCATTGTGGTCGACGCCGACCT
GCTCACCACCAATGTGCGCCACTTCCCGATGTTCCCGGATCTGCAGCCGCCGTACTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9453.63 Da        Isoelectric Point: 10.6555

>AT131880 WP_003413167.1 NZ_CP041831:c1803814-1803557 [Mycobacterium tuberculosis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Download         Length: 258 bp

>AT131880 NZ_CP041831:c1803814-1803557 [Mycobacterium tuberculosis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ28

Antitoxin

Source ID Structure
AlphaFold DB A0A829C9W5

References