131865

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-mazE/PIN(toxin)
Location 759781..760573 Replicon chromosome
Accession NZ_CP041831
Organism Mycobacterium tuberculosis strain 2-0059P6C4

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB2
Locus tag FPJ77_RS03485 Protein ID WP_003403386.1
Coordinates 760136..760573 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TQE0
Locus tag FPJ77_RS03480 Protein ID WP_003403381.1
Coordinates 759781..760026 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ77_RS03450 754800..756306 + 1507 Protein_681 carotenoid cleavage oxygenase -
FPJ77_RS03455 756387..757397 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
FPJ77_RS03460 757785..758168 - 384 WP_003403365.1 ribonuclease VapC6 -
FPJ77_RS03465 758263..758418 - 156 WP_031582830.1 type II toxin-antitoxin system VapB family antitoxin -
FPJ77_RS03470 758494..759210 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
FPJ77_RS03475 759486..759794 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
FPJ77_RS03480 759781..760026 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family Antitoxin
FPJ77_RS03485 760136..760573 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin Toxin
FPJ77_RS03490 760570..760824 - 255 WP_003911263.1 antitoxin VapB7 -
FPJ77_RS03495 760938..763301 + 2364 WP_031582834.1 arylsulfatase AtsD -
FPJ77_RS03500 763364..763690 + 327 WP_003403401.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FPJ77_RS03505 763602..763940 + 339 WP_003403405.1 PIN domain-containing protein -
FPJ77_RS03510 763937..764110 + 174 WP_003898549.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15245.39 Da        Isoelectric Point: 5.1865

>T131865 WP_003403386.1 NZ_CP041831:c760573-760136 [Mycobacterium tuberculosis]
MIVLDTTVLVYAKGAEHPLRDPCRDLVAAIADERIAATTTAEVIQEFVHVRARRRDRSDAAALGRVTMPNCSRRYSPSIE
ATSKRGLTLFETTPGLEACDAVLAAVAASAGATALVSADPAFADLSDVVHVIPDAAGMVSLLGDR

Download         Length: 438 bp

>T131865 NZ_CP041831:c760573-760136 [Mycobacterium tuberculosis]
ATGATAGTGCTCGACACCACCGTCCTCGTCTATGCCAAAGGCGCCGAGCATCCACTCCGCGATCCCTGCCGCGATCTCGT
CGCGGCAATCGCCGACGAACGCATCGCTGCGACCACCACCGCCGAGGTGATCCAGGAGTTCGTCCACGTACGCGCCCGCC
GGCGCGACCGCAGCGACGCCGCCGCGCTGGGCCGTGTGACTATGCCGAACTGCTCTCGCCGCTACTCACCATCAATCGAG
GCCACCTCGAAGCGCGGCCTGACGCTGTTCGAGACAACGCCAGGGCTTGAAGCCTGCGACGCGGTGCTCGCGGCGGTTGC
CGCAAGCGCCGGCGCGACCGCTCTTGTCTCGGCTGACCCGGCGTTCGCCGATCTGTCGGATGTCGTGCACGTCATTCCCG
ACGCGGCCGGGATGGTCAGCCTGCTCGGCGACCGCTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9169.01 Da        Isoelectric Point: 4.2070

>AT131865 WP_003403381.1 NZ_CP041831:c760026-759781 [Mycobacterium tuberculosis]
MLSFRADDHDVDLADAWARRLHIGRSELLRDALRRHLAALAADQDVQAYTERPLTDDENALAEIADWGPAEDWADWADAA
R

Download         Length: 246 bp

>AT131865 NZ_CP041831:c760026-759781 [Mycobacterium tuberculosis]
ATGCTCAGCTTCCGCGCCGACGACCACGACGTCGACCTGGCCGACGCGTGGGCGCGTCGCCTACACATCGGCCGCTCCGA
GCTGCTGCGCGATGCGCTGCGACGTCACTTGGCCGCGCTGGCCGCGGACCAGGATGTCCAGGCCTACACCGAGCGACCGT
TGACGGACGACGAGAACGCACTGGCTGAGATCGCCGACTGGGGGCCGGCGGAGGACTGGGCCGACTGGGCCGATGCGGCG
CGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSW5

Antitoxin

Source ID Structure
AlphaFold DB G0TQE0

References