Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2852679..2853319 Replicon chromosome
Accession NZ_CP041830
Organism Mycobacterium tuberculosis strain 2-0068P6C4

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ08
Locus tag FPJ78_RS13245 Protein ID WP_003412970.1
Coordinates 2852679..2853098 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ09
Locus tag FPJ78_RS13250 Protein ID WP_003412975.1
Coordinates 2853095..2853319 (-) Length 75 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ78_RS13215 2848269..2848991 - 723 WP_003412957.1 DUF1906 domain-containing protein -
FPJ78_RS13220 2849508..2849730 + 223 Protein_2609 type II toxin-antitoxin system VapB family antitoxin -
FPJ78_RS13225 2849727..2850128 + 402 WP_003412963.1 PIN domain-containing protein -
FPJ78_RS13230 2850163..2851083 - 921 WP_003412965.1 restriction endonuclease -
FPJ78_RS13235 2851424..2851669 - 246 WP_071854223.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
FPJ78_RS13240 2851728..2852678 + 951 WP_003911916.1 Lsr2 family protein -
FPJ78_RS13245 2852679..2853098 - 420 WP_003412970.1 type II toxin-antitoxin system VapC family toxin Toxin
FPJ78_RS13250 2853095..2853319 - 225 WP_003412975.1 antitoxin VapB39 Antitoxin
FPJ78_RS13255 2853350..2856193 - 2844 WP_003899363.1 aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme -
FPJ78_RS13260 2856265..2856666 - 402 WP_003412981.1 hypothetical protein -
FPJ78_RS13265 2856666..2857136 - 471 WP_003899364.1 transcription antitermination factor NusB -
FPJ78_RS13270 2857139..2857702 - 564 WP_003412989.1 elongation factor P -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-128)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 140 a.a.        Molecular weight: 14732.70 Da        Isoelectric Point: 6.7519

>T131832 WP_003412970.1 NZ_CP041830:c2853098-2852679 [Mycobacterium tuberculosis]
VTALLDVNVLIALGWPNHVHHAAAQRWFTQFSSNGWATTPITEAGYVRISSNRSVMQVSTTPAIAIAQLAAMTSLAGHTF
WPDDVPLIVGSAGDRDAVSNHRRVTDCHLIALAARYGGRLVTFDAALADSASAGLVEVL

Download         Length: 420 bp

>T131832 NZ_CP041830:c2853098-2852679 [Mycobacterium tuberculosis]
GTGACGGCACTGCTCGATGTCAATGTGCTGATCGCGCTGGGCTGGCCGAATCACGTTCACCATGCGGCCGCGCAGCGATG
GTTCACGCAGTTCTCCTCGAATGGGTGGGCCACCACGCCGATCACCGAGGCAGGGTATGTCCGAATTTCAAGCAATCGCA
GTGTGATGCAGGTGTCGACCACGCCGGCTATCGCGATCGCTCAGTTGGCGGCGATGACTTCTCTTGCCGGGCACACGTTT
TGGCCTGACGATGTGCCACTGATCGTTGGGAGCGCCGGCGATCGCGATGCGGTGTCCAACCACCGTCGGGTCACCGACTG
CCATCTCATCGCCTTGGCCGCGCGCTACGGGGGCCGGTTGGTCACATTCGATGCCGCACTGGCCGATTCAGCATCCGCAG
GCCTCGTCGAGGTGTTGTAG

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 7993.94 Da        Isoelectric Point: 4.0057

>AT131832 WP_003412975.1 NZ_CP041830:c2853319-2853095 [Mycobacterium tuberculosis]
MRTTLQIDDDVLEDARSIARSEGKSVGAVISELARRSLRPVGIVEVDGFPVFDVPPDAPTVTSEDVVRALEDDV

Download         Length: 225 bp

>AT131832 NZ_CP041830:c2853319-2853095 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGCAGATTGATGATGATGTTCTAGAAGATGCTCGTAGCATCGCGCGGTCGGAGGGCAAGTCAGTCGG
CGCGGTAATTTCTGAGTTGGCGCGTAGGTCGCTCCGTCCGGTTGGGATTGTCGAGGTTGACGGATTTCCGGTTTTTGATG
TTCCGCCGGATGCGCCGACGGTGACTTCCGAGGATGTCGTCCGCGCGCTCGAGGACGACGTGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G0TQ08


Antitoxin

Source ID Structure
AlphaFold DB G0TQ09

References