Detailed information of TA system TA131812

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1385798..1386486
• Replicon: chromosome
• Accession: NZ_CP041830
• Organism: Mycobacterium tuberculosis strain 2-0068P6C4

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0THR7
• Locus tag: FPJ78_RS06510
• Protein ID: WP_003406304.1
• Coordinates: 1386055..1386486 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0THR6
• Locus tag: FPJ78_RS06505
• Protein ID: WP_003406302.1
• Coordinates: 1385798..1386058 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPJ78_RS06485	1381375..1382199	+	825	WP_003900298.1	trehalose ABC transporter permease SugB	-
FPJ78_RS06490	1382204..1383385	+	1182	WP_003406299.1	trehalose ABC transporter ATP-binding protein SugC	-
FPJ78_RS06495	1383462..1384562	-	1101	WP_003406300.1	magnesium/cobalt transporter CorA	-
FPJ78_RS06500	1384733..1385722	+	990	WP_003406301.1	malate dehydrogenase	-
FPJ78_RS06505	1385798..1386058	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	Antitoxin
FPJ78_RS06510	1386055..1386486	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	Toxin
FPJ78_RS06515	1386509..1388092	-	1584	WP_009940130.1	PE family protein	-
FPJ78_RS06520	1388272..1389132	+	861	WP_003900301.1	hypothetical protein	-
FPJ78_RS06525	1389213..1390043	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
FPJ78_RS06530	1390100..1390393	-	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	-
FPJ78_RS06535	1390390..1390659	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (2-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 15873.08 Da
• Isoelectric Point: 5.8838

>T131812 WP_003406304.1 NZ_CP041830:1386055-1386486 [Mycobacterium tuberculosis]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Nucleotide

• Length: 432 bp

>T131812 NZ_CP041830:1386055-1386486 [Mycobacterium tuberculosis]
GTGATCATCCCTGACATCAATCTGCTGCTCTACGCGGTCATCACCGGATTCCCGCAGCACCGGCGCGCGCATGCGTGGTG
GCAAGACACCGTCAACGGCCACACCCGTATCGGGCTGACGTATCCGGCGTTGTTCGGGTTCCTACGGATCGCCACCAGTG
CCCGCGTGCTCGCCGCGCCACTGCCAACCGCGGATGCGATCGCCTATGTGCGCGAGTGGCTTTCGCAGCCGAACGTGGAC
CTACTCACGGCGGGTCCGCGCCACCTGGACATCGCGTTGGGCCTGCTCGACAAGCTCGGCACAGCCAGCCACCTAACCAC
CGATGTGCAACTGGCCGCCTACGGCATCGAATACGACGCCGAGATCCATTCCAGTGACACCGACTTTGCCCGATTCGCCG
ATCTGAAGTGGACCGACCCGTTGCGCGAATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9918.25 Da
• Isoelectric Point: 6.4755

>AT131812 WP_003406302.1 NZ_CP041830:1385798-1386058 [Mycobacterium tuberculosis]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Nucleotide

• Length: 261 bp

>AT131812 NZ_CP041830:1385798-1386058 [Mycobacterium tuberculosis]
ATGCGCACCACCTTGACGCTCGATGACGACGTCGTCCGGCTGGTCGAAGACGCAGTGCATCGCGAACGCCGCCCGATGAA
GCAGGTCATCAACGATGCGCTGCGCAGAGCGCTGGCGCCGCCGGTGAAACGGCAGGAGCAGTATCGGTTGGAGCCGCATG
AGTCGGCTGTGCGTTCCGGGTTGGATCTGGCCGGCTTCAACAAGTTGGCCGACGAACTGGAGGATGAGGCGCTGCTGGAT
GCCACGCGTCGGGCCCGGTGA

Structures

Toxin

• AlphaFold DB: G0THR7

Antitoxin

• AlphaFold DB: G0THR6