131791

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) Rv0298-Rv0299/-
Location 361670..362196 Replicon chromosome
Accession NZ_CP041830
Organism Mycobacterium tuberculosis strain 2-0068P6C4

Toxin (Protein)


Gene name Rv0299 Uniprot ID -
Locus tag FPJ78_RS01570 Protein ID WP_003401560.1
Coordinates 361894..362196 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name Rv0298 Uniprot ID P9WJ08
Locus tag FPJ78_RS01565 Protein ID WP_003401555.1
Coordinates 361670..361897 (+) Length 76 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ78_RS01550 357363..358166 - 804 WP_003401540.1 hypothetical protein -
FPJ78_RS01555 358176..359573 - 1398 WP_003401544.1 sulfatase -
FPJ78_RS01560 359752..361527 + 1776 WP_010886074.1 PE family protein -
FPJ78_RS01565 361670..361897 + 228 WP_003401555.1 ribbon-helix-helix protein, CopG family Antitoxin
FPJ78_RS01570 361894..362196 + 303 WP_003401560.1 toxin-antitoxin system toxin Toxin
FPJ78_RS01575 362244..362465 + 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 -
FPJ78_RS01580 362462..362887 + 426 WP_003401566.1 PIN domain nuclease -
FPJ78_RS01585 363023..363655 + 633 WP_003905275.1 TetR/AcrR family transcriptional regulator -
FPJ78_RS01590 363652..364560 + 909 WP_003900117.1 SDR family NAD(P)-dependent oxidoreductase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(6-41)


Sequences


Toxin        


Download         Length: 101 a.a.        Molecular weight: 10442.16 Da        Isoelectric Point: 4.9609

>T131791 WP_003401560.1 NZ_CP041830:361894-362196 [Mycobacterium tuberculosis]
MIAPGDIAPRRDSEHELYVAVLSNALHRAADTGRVITCPFIPGRVPEDLLAMVVAVEQPNGTLLPELVQWLHVAALGAPL
GNAGVAALREAASVVTALLC

Download         Length: 303 bp

>T131791 NZ_CP041830:361894-362196 [Mycobacterium tuberculosis]
TTGATCGCTCCCGGCGACATCGCGCCGCGCCGCGACAGTGAACACGAGCTCTACGTCGCCGTCTTGTCCAACGCGCTCCA
TCGGGCCGCGGACACCGGACGGGTGATCACCTGCCCATTCATTCCGGGCCGGGTCCCCGAGGATCTCTTGGCGATGGTGG
TGGCGGTCGAGCAACCCAACGGCACGCTGCTGCCGGAACTCGTGCAGTGGCTTCATGTTGCCGCGCTCGGTGCGCCACTC
GGCAACGCGGGCGTGGCCGCCCTACGCGAGGCTGCCTCGGTCGTGACAGCTCTGCTCTGTTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8130.21 Da        Isoelectric Point: 7.0084

>AT131791 WP_003401555.1 NZ_CP041830:361670-361897 [Mycobacterium tuberculosis]
MTKEKISVTVDAAVLAAIDADARAAGLNRSEMIEQALRNEHLRVALRDYTAKTVPALDIDAYAQRVYQANRAAGS

Download         Length: 228 bp

>AT131791 NZ_CP041830:361670-361897 [Mycobacterium tuberculosis]
ATGACGAAAGAGAAGATCTCCGTGACGGTGGACGCGGCCGTCCTCGCGGCGATCGACGCGGACGCCAGGGCGGCGGGTTT
GAATCGGTCGGAAATGATTGAGCAGGCACTGCGCAACGAGCACCTGCGTGTCGCTCTGCGCGATTACACGGCTAAAACCG
TACCGGCGTTGGACATCGATGCCTACGCACAGCGGGTGTACCAGGCGAACCGAGCGGCCGGAAGTTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A7U4F8T1

References