Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 1019809..1020428 Replicon chromosome
Accession NZ_CP041829
Organism Mycobacterium tuberculosis strain 3-0059P6C4

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag FPJ79_RS04810 Protein ID WP_003404726.1
Coordinates 1019994..1020428 (+) Length 145 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ06
Locus tag FPJ79_RS04805 Protein ID WP_003898641.1
Coordinates 1019809..1019988 (+) Length 60 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ79_RS04790 1015282..1016862 + 1581 WP_176748817.1 serine hydrolase -
FPJ79_RS04795 1016859..1019252 + 2394 WP_003898639.1 cation-translocating P-type ATPase -
FPJ79_RS04800 1019525..1019683 + 159 WP_003404720.1 hypothetical protein -
FPJ79_RS04805 1019809..1019988 + 180 WP_003898641.1 antitoxin Antitoxin
FPJ79_RS04810 1019994..1020428 + 435 WP_003404726.1 SRPBCC family protein Toxin
FPJ79_RS04815 1020526..1021299 + 774 WP_003404735.1 VOC family protein -
FPJ79_RS04820 1021364..1021813 + 450 WP_003404738.1 hypothetical protein -
FPJ79_RS04825 1021948..1022178 - 231 WP_003898642.1 hypothetical protein -
FPJ79_RS04830 1022345..1023853 - 1509 WP_003404742.1 carotenoid oxygenase family protein -
FPJ79_RS04835 1023855..1025093 - 1239 WP_003404744.1 acetyl-CoA acetyltransferase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-142)

Antitoxin

(4-50)


Sequences


Toxin        


Download         Length: 145 a.a.        Molecular weight: 15754.47 Da        Isoelectric Point: 9.7977

>T131748 WP_003404726.1 NZ_CP041829:1019994-1020428 [Mycobacterium tuberculosis]
MAKLSGSIDVPLPPEEAWMHASDLTRYREWLTIHKVWRSKLPEVLEKGTVVESYVEVKGMPNRIKWTIVRYKPPEGMTLN
GDGVGGVKVKLIAKVAPKEHGSVVSFDVHLGGPALLGPIGMIVAAALRADIRESLQNFVTVFAG

Download         Length: 435 bp

>T131748 NZ_CP041829:1019994-1020428 [Mycobacterium tuberculosis]
ATGGCGAAACTGTCCGGATCCATCGACGTACCGCTGCCACCGGAGGAAGCCTGGATGCACGCCTCCGATCTGACTCGTTA
CCGAGAGTGGCTGACCATCCACAAGGTATGGCGCAGCAAGTTGCCCGAAGTGCTCGAGAAGGGCACGGTCGTCGAGTCGT
ATGTCGAGGTCAAGGGCATGCCCAACCGGATCAAGTGGACGATCGTGCGGTACAAACCCCCGGAGGGCATGACGCTCAAC
GGCGACGGTGTGGGTGGTGTCAAAGTCAAGCTGATCGCTAAGGTAGCGCCGAAAGAGCACGGCTCCGTCGTCAGCTTCGA
TGTGCACCTCGGCGGCCCGGCCCTGCTCGGGCCGATCGGCATGATCGTCGCCGCTGCATTGCGAGCCGACATCCGCGAAT
CGCTGCAGAACTTCGTCACGGTGTTTGCCGGCTGA

Antitoxin


Download         Length: 60 a.a.        Molecular weight: 6403.07 Da        Isoelectric Point: 4.5393

>AT131748 WP_003898641.1 NZ_CP041829:1019809-1019988 [Mycobacterium tuberculosis]
MGILDKVKNLLSQNADKVETVINKAGEFVDEQTQGNYSDAIHKLHDAASNVVGMSDQQS

Download         Length: 180 bp

>AT131748 NZ_CP041829:1019809-1019988 [Mycobacterium tuberculosis]
ATGGGAATCCTGGACAAGGTAAAGAACCTGCTGTCGCAGAACGCCGACAAGGTCGAGACGGTGATCAACAAAGCGGGCGA
ATTCGTCGACGAGCAGACGCAAGGCAATTATTCTGACGCCATCCACAAGCTGCATGACGCGGCCAGCAACGTCGTCGGCA
TGAGCGACCAGCAGAGCTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A045KDK5

References