Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2956647..2957361 Replicon chromosome
Accession NZ_CP041827
Organism Mycobacterium tuberculosis strain 3-0096P6C4

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag FPJ81_RS13705 Protein ID WP_003413460.1
Coordinates 2956921..2957361 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag FPJ81_RS13700 Protein ID WP_003413456.1
Coordinates 2956647..2956934 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ81_RS13665 2952069..2952314 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
FPJ81_RS13670 2952311..2952715 + 405 WP_003413432.1 type II toxin-antitoxin system VapC family toxin -
FPJ81_RS13675 2952932..2953552 + 621 WP_003413441.1 DUF4178 domain-containing protein -
FPJ81_RS13680 2953563..2954057 + 495 WP_003413444.1 DUF2617 family protein -
FPJ81_RS13685 2954054..2954485 + 432 WP_003413445.1 DUF4247 domain-containing protein -
FPJ81_RS13690 2954510..2954968 + 459 WP_003413451.1 DUF350 domain-containing protein -
FPJ81_RS13695 2954965..2956536 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
FPJ81_RS13700 2956647..2956934 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
FPJ81_RS13705 2956921..2957361 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
FPJ81_RS13710 2957382..2958137 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
FPJ81_RS13715 2958270..2958866 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
FPJ81_RS13720 2958874..2959719 - 846 WP_003413466.1 acyl-CoA thioesterase II -
FPJ81_RS13725 2959748..2960647 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
FPJ81_RS13730 2960775..2961449 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T131655 WP_003413460.1 NZ_CP041827:2956921-2957361 [Mycobacterium tuberculosis]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T131655 NZ_CP041827:2956921-2957361 [Mycobacterium tuberculosis]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT131655 WP_003413456.1 NZ_CP041827:2956647-2956934 [Mycobacterium tuberculosis]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT131655 NZ_CP041827:2956647-2956934 [Mycobacterium tuberculosis]
ATGAAGACCACGCTCGACCTGCCTGATGAACTGATGCGCGCTATCAAGGTCCGCGCGGCGCAGCAGGGCCGCAAGATGAA
AGATGTCGTGACCGAACTGCTCAGATCCGGTCTGTCCCAGACGCACAGCGGGGCTCCAATCCCAACGCCGCGGCGCGTGC
AGCTTCCCCTGGTGCATTGCGGTGGCGCGGCTACCCGCGAACAAGAAATGACGCCGGAGCGTGTTGCCGCGGCCTTGCTC
GACCAGGAGGCCCAGTGGTGGTCCGGACACGACGATGCTGCTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References